参考标题:Biosynthesis. Part 24. Speculative Incorporation Experiments With 1-Benzylisoquinolines And A Logical Approach Via C6-C2And C6-C3Precursors To The Biosynthesis Of Hasubanonine And Protostephanine 作者:Alan R. Battersby,Raymond C. F. Jones,Rymantas Kazlauskas,Craig W. Thornber,Somsak Ruchirawat,James Staunton 摘要:Many Possible 1-Benzyltetrahydroisoquinolines Have Been Examined As Possible Advanced Precursors Of The Alkaloids Hasubanonine (1) And Protostephanine (2) In Stephania Japonica Plants, But None Was Incorporated Significantly. Administration Of Various Precursor Molecules Having Only One Aromatic Ring, Such As Tyrosine, Has Demonstrated That Both Alkaloids Are Derived From Two Different C6-C2 Biogenetic
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参考文献:10.1021/cb400400j 摘要:Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martínez-Sobrido L, LaVoie EJ, Das K, Arnold E. Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. ACS Chem Biol. 2013 Nov 15;8(11):2501–8.