CAS: 41046-70-2; 2-Iodo-5-Methoxyphenol

上下游产品

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📜3-甲氧基苯酚置于碘,Silver Trifluoromethanesulfonate体系中,用72%的收率获得产物2-碘-5-甲氧基苯酚
参考文献:合成毛孔的界面工程:面向超灵敏的生物传感器.
标题:合成毛孔的界面工程:面向超灵敏的生物传感器.
摘要:引入亲水锚固作为一种有前途的策略,以建设性地控制合成孔隙传感器与周围双相环境的各种相互作用.选择人造硬质β桶作为经典的合成多功能孔,并附有无规卷曲的四赖氨酸作为亲水锚.该先进的孔的合成是从市售起始原料开始的32个步骤中完成的.就孔隙活性而言,亲水性锚固的关键影响是从希尔系数n <1到n = 4的变化.该变化证实了成功的抑制竞争性自组装,其中自水相的沉淀是孔隙活性的成功增加的根源.亲水锚不干扰阴离子分析物对合成孔传感器的阻塞.在阻滞剂的化学计量结合中(k(d)=孔隙的ec(50); Ec(50)=观测到50%孔隙活性所需的浓度),通过亲水性锚固实现的孔隙活性增加导致在高稀释条件下改善了孔堵塞.对照确认,这种增加不会发生于不具有化学计量结合的分析物(k(d)> Ec(50)).这些结果不仅表明化学计量结合是合成孔传感器灵敏度极限的预期来源,而且还为该问题提供了有希望的解决方案.亲水锚固与靶向孔
DOI:10.1002/chem.200701520

专利信息

专利号:US-2005130221-A1
优先权日:2001-02-01
标 题:Synthesis for the preparation of compounds for screening as potential tubulin binding agents
发明人：FLYNN BERNARD L; HAMEL ERNEST
权利人:US GOV HEALTH & HUMAN SERV
摘要:The present invention relates to methods for the synthesis of chemical compounds for screening as potential tubulin polymerization inhibitors. The invention also provides chemical compounds with tubulin polymerization inhibitor activity.

专利号:US-4652584-A
优先权日:1984-07-13
标 题 :Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
发明人：CARSON JOHN R
权利人:MCNEILAB INC
摘要:Phenoxypropanol derivatives having a 2-acetylenic moiety on the phenyl group thereof of the following formula (I): ##STR1## and their use as anti-hypertensives, e.g. in man. Also part of the invention are pharmaceutical compositions and intermediates used in the synthesis.

专利号:CA-2435545-A1
优先权日:2001-02-01
标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents

专利号:EP-1363880-A1
优先权日:2001-02-01
标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents

专利号:EP-1363880-A4
优先权日:2001-02-01
标题:SYNTHESIS FOR THE PREPARATION OF COMPOUNDS FOR SCREENING AS POTENTIAL TUBULIN BINDING MEDIUM

专利号:NZ-527029-A
优先权日:2001-02-01
标题 :Synthesis for the preparation of compounds for screening as potential tubulin binding agents