CAS: 37705-82-1; 2,4-Diaminobenzonitrile

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CAS号4110-33-2 2,4-二硝基苯甲腈

📜2,4-二硝基苯甲腈置于盐酸,Tin(Ll) Chloride体系中,化学反应生成 5-氨基-2-氟苯甲腈
参考文献:N,N'-(Phenylene)Dioxamic Acids And Their Esters As Antiallergy Agents
标题:N,N'-(Phenylene)Dioxamic Acids And Their Esters As Antiallergy Agents
摘要:A Series Of Dialkyl N,N'-(M-Phenylene)Dioxamates Was Synthesized By Treatment Of The Requisite M-Phenylenediamines With An Alkyloxalyl Chloride In The Presence Of Triethylamine. Hydrolysis With Sodium Hydroxide Solution Gave The Corresponding N,N'-(M-Phenylene)Dioxamic Acids. Several N,N'-(P-Phenylene)Dioxamic Acids Were Synthesized Also In The Same Manner Starting With The Requisite P-Phenylenediamines. These Compounds Were Tested In The Rat Passive Cutaneous Anaphylaxis (Pca) Assay. When Tested Iv,Activity Was Found In The N,N'-(M-Phenylene) Dioxamic Acids Up To 2500 Times That Shown By Disodium Cromoglycate [50% Inhibition At 0.001 Mg/kg For N,N'-(2-Chloro-5-Cyano-M-Phenylene)Dioxamic Acid (Compound 61)]. Oral Activity Was Seen In This Series Of Compounds With Duration Of Activity Up To 120 Min. Oral Activity Was Detected In Diethyl N,N'-(2-Chloro-5-Cyano-M-Phenylene)Dioxamate (Compound 38) At Levels Of Drug As Low As 0.1 Mg/kg.
DOI:10.1021/jm00207A016