CAS: 35973-17-2; 8-Bromo-4-Hydroxy-3-Quinolinecarboxylic Acid

相似化合物

35975-57-6 98948-95-9 860205-92-1

上下游产品

8-溴-4-羟基喹啉-3-羧酸乙酯 Ethyl 8-Bromo-4-Oxo-1,4-Dihydroquinoline-3-Carboxylate 35975-57-6

📜2-[(2-Bromo-Phenylamino)Methylene]Malonic Acid Diethyl Ester置于sodium Hydroxide体系中,用 二苯醚,水 作为反应溶剂,化学反应 5.0H,反应生成 8-溴-4-羟基喹啉-3-羧酸
参考文献:Investigations On The 4-Quinolone-3-Carboxylic Acid Motif. 4. Identification Of New Potent And Selective Ligands For The Cannabinoid Type 2 Receptor With Diverse Substitution Patterns And Antihyperalgesic Effects In Mice
标题:Investigations On The 4-Quinolone-3-Carboxylic Acid Motif. 4. Identification Of New Potent And Selective Ligands For The Cannabinoid Type 2 Receptor With Diverse Substitution Patterns And Antihyperalgesic Effects In Mice
摘要:Experimental Evidence Suggests That Selective Cb2 Receptor Modulators May Provide Access To Antihyperalgesic Agents Devoid Of Psychotropic Effects. Talcing Advantage Of Previous Findings On Structure-Activity/selectivity Relationships For A Class Of 4-Quinolone-3-Carboxamides,Further Structural Modifications Of The Heterocyclic Scaffold Were Explored,Leading To The Discovery Of The 8-Methoxy Derivative 4A Endowed With The Highest Affinity And Selectivity Ever Reported For A Cb2 Ligand. The Compound,Evaluated In Vivo In The Formalin Test,Behaved As An Inverse Agonist By Reducing At A Dose Of 6 Mg/kg The Second Phase Of The Formalin-Induced Nocifensive Response In Mice.
DOI:10.1021/jm200476P