CAS: 299-88-7; 4-(N-((4-Amino-2-Methylpyrimidin-5-yl)Methyl)Formamido)-3-(Benzoylthio)Pent-3-En-1-Yl Benzoate

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CAS号67-03-8 盐酸硫胺

📜盐酸硫胺 在 Sodium Hydroxide,水体系中,获得 O,S-Dibenzoylthiamine
参考文献:Gene Expression Of Cyclooxygenase In The Aging Heart
标题:Gene Expression Of Cyclooxygenase In The Aging Heart
摘要:Cyclooxygenase (Cox) Is The Key Rate-Limiting Enzyme In The Prostaglandin Synthetic Pathway. Two Isoforms Of Cox Have Been Identified: A Constitutive Cox-1 And An Inducible Cox-2,Which Is Activated In Response To Various Stimuli. We Investigated The Changes Of Cox-1 And Cox-2 In Rat Heart During Aging. We Measured The Age-Related Changes In The Mrna And Protein Levels Of Cox By Using Reverse-Transcription Polymerase Chain Reaction And Western Blotting,Respectively. Cox-2 Mrna And Protein Levels Increased With Age,Whereas Those Of Cox-1 Showed No Change. The Cox Activity Determined By Prostaglandin E-2 Production Increased With Age. Because The Cox-Catalyzed Arachidonate Cascade Is An Important Source Of Reactive Oxygen Species (Ros) Generation,Changes In Ros Generation And Lipid Peroxidation Were Also Assessed. The Amount Of Ros Generated By The Cox Pathway Increased With Age,As Did The Total Ros Generation And Lipid Peroxidation. These Results Show That Cox-2 Activity Increases With Age,Partially Because Of Elevated Transcriptional Expression And Protein Content,And They Suggest That Increased Cox-2 Can Play A Role In Oxidative Alterations In The Aged Heart.
Doi:10.1093/Gerona/56.8.B350