[acetyl(Methoxycarbonyl)Methylene]Triphenylphosphorane 以71%的收率获得2-丁炔酸甲酯 参考文献:Synthesis And Spectroscopic Characterization Of 1-13C-And 4-13C-Plastoquinone-9 标题:Synthesis And Spectroscopic Characterization Of 1-13C-And 4-13C-Plastoquinone-9 摘要: Doi:10.1002/1099-0690(200207)2002:13<2094::Aid-Ejoc2094>3.0.Co;2-E
专利号:US-8153839-B2 优先权日:2005-09-14 标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound 发明人:OGO SEIJI; FUKUZUMI SHUN-ICHI 权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY 摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.
专利号:US-3872101-A 优先权日:1969-04-11 标题:Synthesis of {60 , {62 -unsaturated compounds 发明人:SIDDALL JOHN E; FRIED JOHN H 权利人:ZOECON CORP 摘要:Stereospecific synthesis of Alpha , Beta -ethylenically unsaturated compounds by the reaction of an organo-copper or organo-manganese reagent with an Alpha , Beta -acetylenically unsaturated compound at a temperature of -40*C or less.
专利号:US-8796454-B2 优先权日:2012-05-04 标 题 :Synthesis of [2.2.2]-diazabicyclic ring systems 发明人:SCHEERER JONATHAN R 权利人:COLLEGE WILLIAM & MARY 摘要:Herein we describe compositions and methods for the synthesis of [2.2.2]-diazabicyclic structures comprising a domino reaction sequence involving aldol condensation, alkene isomerization, and intramolecular hetero-Diels-Alder cycloaddition. Excellent diastereofacial control during the cycloaddition is enforced with a removable chiral phenyl aminal diketopiperazine substituent. The reaction sequence rapidly generates molecular complexity and is competent with both enolizable and non-enolizable aldehyde substrates. This method provides an efficient route to [2.2.2]-diazabicyclic structures, common to bioactive prenylated indole alkaloids such as the brevianamides and stephacidins.
专利号:US-8268936-B2 优先权日:2005-01-04 标题:Synthesis of hybrid block copolymers and uses thereof 发明人:BREITENKAMP KURT; SILL KEVIN N 权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC 摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.
专利号:US-2012196989-A1 优先权日:2005-02-11 标题:Synthesis of homopolymers and block copolymers 发明人:BREITENKAMP KURT; SILL KEVIN N 权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC 摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.
专利号:US-2024417420-A1 优先权日:2021-10-04 标题:Polar cd33 ligands suitable for incorporation into carriers 发明人:MAGNANI JOHN L; PETERSON JOHN M; GHOSH LNDRANATH; NOGUEIRA JASON; RAHMAN MITI 权利人:GLYCOMIMETICS INC 摘要:CD33 ligands which are useful for the synthesis of CD33 ligand-bearing carriers, wherein said CD33 ligand-bearing carriers are directly or indirectly linked to or associated with at least one anti-cancer agent, are described herein. Uses of said CD33 ligand-bearing carriers for treating and/or preventing a disease, disorder, or condition such as acute myeloid leukemia (AML) are also described.
参考标题:Regioselective Synthesis Of 2,3,4-Trisubstituted Pyrroles Via Pd(II)-Catalyzed Three-Component Cascade Reactions Of Amines, Alkyne Esters, And Alkenes 作者:Xu Zhang,Xuefeng Xu,Gong Chen,Wei Yi |发布日期:2016.10.7 摘要:Three-Component Cascade Reaction Of Diverse Amines, Alkyne Esters, And Alkenes Is Disclosed For The Direct Synthesis Of Diverse 2,3,4-Trisubstituted Pyrroles With Broad Functional Group Tolerance And In Good To Excellent Yields. This Transformation Is Supposed To Proceed Through The Cascade Formation Of C(Sp2)-C(Sp2) And C(Sp2)-N Bonds Via Pd(II)-Catalyzed Regioselective Alkene Migratory Insertion, Intramolecular
合成参考文献
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