CAS: 21887-64-9; Boc-Orn-Oh

相似化合物

159877-12-0 109425-55-0 13650-49-2

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Boc-L-天冬氨酸二甲酯置于咪唑,甲醇,4-二甲氨基吡啶,Platinum(Iv) Oxide,Sodium Tetrahydroborate,氢气,碘,二异丁基氢化铝,三苯基膦,三氟乙酸,Lithium Hydroxide体系中,用 四氢呋喃,1,4-二氧六环,甲醇,乙醚,二氯甲烷,水,N,N-二甲基甲酰胺,乙腈 用作溶剂,-78.0~20.0 °C,101.33 Kpa 条件下,反应 50.58H,反应生成Boc-L-鸟氨酸
参考文献:铁(II)和 2-(氧代)戊二酸依赖性加氧酶对 C-C 去饱和的两种不同机制:α-杂原子辅助的重要性
标题:铁(II)和 2-(氧代)戊二酸依赖性加氧酶对 C-C 去饱和的两种不同机制:α-杂原子辅助的重要性
摘要:非血红素 Fe(Iv)-氧代 (Ferryl) 络合物对脂肪族碳的羟基化通过氢原子 (H•) 转移 (Hat) 到 Ferryll 以及随后碳自由基与 Fe(III) 配位氧之间的耦合(称为回弹)进行).使用 H•-抽象弗瑞尔复合物进行其他转化的酶必须抑制反弹或进一步加工羟基化中间体.对于安装烯烃的 Cc 去饱和,有人提出从碳 α 到自由基抢占 Fe(III)-Oh 复合物的第二个 Hat 反弹.第二个站点的氘 (2H) 应该会减慢这一步,从而可能使反弹具有竞争力.由两种相关的 L-精氨酸修饰铁 (II) 和 2-(氧代)戊二酸依赖性 (Fe/2Og) 加氧酶介导的去饱和在该关键测试中表现相反,暗示了不同的机制.Napl,L-Arg 4,来自萘啶霉素生物合成途径的 5-去饱和酶首先从 C5 中提取 H•,但无论 C4 是否含有 1H 或 2H,都会以相同的适度程度将该位点羟基化(导致胍释放).相比之下,当
Doi:10.1021/jacs.8B01933

专利信息

专利号:US-6359144-B1
优先权日:1997-02-04
标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-4301065-A
优先权日:1977-05-25
标 题 :Novel polypeptides having thymic activity or an antagonistic activity and processes for their synthesis
发明人：BACH JEAN-FRANCOIS; DARDENNE MIREILLE; PLEAU JEAN-MARIE; HAMBURGER JEAN; BRICAS EVANGHELOS; MARTINEZ JEAN; BLANOT DIDIER; AUGER GENEVIEVE
权利人:ANVAR
摘要:The invention is concerned with novel polypeptides and processes for the synthesis thereof. It is concerned with compounds having the sequence X-Gln-Gly-Gly-Y in which Y represents -Ser-Asn and X represents Ser-, Lys-Ser-, Ala-Lys-Ser-, Glx-Ala-Lys-Ser-; Glx representing Pyro-Glu or Gln; and when X represents Glx-Ala-Lys-Ser-, Y may in addition represent -Ser; as well as their derivatives comprising one or two modified amino acids, with the exception of the unmodified compound PyroGlu-Ala-Lys-Ser-Gln-Gly-Ser-Asn. These polypeptides are useful as medicines.

专利号:US-6417195-B1
优先权日:1999-02-22
标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAL
权利人:LION BIOSCIENCE AG
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

专利号:US-5874443-A
优先权日:1995-10-19
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

专利号:WO-0050406-A1
优先权日:1999-02-22
标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAEL
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.

专利号:US-5777153-A
优先权日:1994-07-08
标题 :Cationic lipids
发明人：LIN KUEI-YING; LEWIS JASON G; MATTEUCCI MARK D; WAGNER RICHARD W
权利人:GILEAD SCIENCES INC
摘要:The present invention is directed to new cationic lipids and intermediates in their synthesis that are useful for transfecting nucleic acids or peptides into prokaryotic or eukaryotic cells. The lipids comprise one or two arginine, lysine or ornithine residues linked to a lipophilic moiety. The lipids form a composition when mixed with polyanions such as nucleic acids. The compositions permit efficient transfer of polyanions into cells without significant toxicity to the cells.