CAS: 2160-62-5; 5-Bromothiophene-2-Carbonitrile

该化合物是一种多用途的七环化合物,在硫苯环上有一个溴替代物和一个硝化物功能组.这一结构使其成为有机合成的宝贵中间体,特别是在制药,农用化学品和功能材料的制作方面.溴原子通过交叉反应促进进一步功能化,而硝化物组为衍生提供了额外的再活动.在标准条件下,其高纯度和稳定性确保了合成应用的可靠性能.该化合物通常用于催化反应,如铃木或Heck联动,使其成为建造复杂的硫苯基建筑的关键建筑.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号2160-63-6 5-溴噻吩-2-甲醛肟 | CAS号1003-31-2 2-氰基噻吩 | CAS号4701-17-1 5-溴噻吩-2-甲醛 | CAS号79-24-3 硝基乙烷 | CAS号18820-82-1 吡啶氢溴酸盐 | CAS号3141-27-3 2,5-二溴噻吩 | CAS号557-21-1 氰化锌 | CAS号98-03-3 2-噻吩甲醛 | CAS号200358-05-0 5-(4-methoxyphe... | CAS号76371-66-9 3-溴噻吩-2-羰基胺 | CAS号612499-04-4 1-(5-溴-2-噻吩基)甲胺 1HCL | CAS号123784-07-6 2-(5-溴噻吩-2-基)吡啶 | CAS号211943-12-3 5-(5-溴-2-噻吩基)-1H-四唑

合成工艺路线路线简述

    📜5-溴噻吩-2-甲醛置于ammonium Hydroxide,碘体系中,用 四氢呋喃 用作溶剂,化学反应 12.0H,以90%的收率获得5-溴噻吩-2-甲腈
    参考文献:调节基于三嗪的共价有机框架的电子结构用于光催化有机转化
    标题:调节基于三嗪的共价有机框架的电子结构用于光催化有机转化
    摘要:凭借可见光吸收能力,共价有机框架(cofs)的能带结构和电子亲和力可以在分子水平上轻松调节,使其成为有吸引力的无金属有机转化光催化剂.然而,Cofs的电子结构与光催化性能之间的关系仍然模糊不清.在这项研究中,我们开发了一种自下而上的策略,通过引入各种构建块来构建三种具有不同电子结构的三嗪基 Cof.硫化物光催化氧化为亚砜表明,缺电子cof比富电子或中性结构具有更高的转化率和选择性,由于缺电子三嗪基cof不仅可以促进电荷的产生和分离,同时也丰富了光催化活性位点.光电化学测量和理论计算进一步证实了这一结果.这项工作通过调制电子结构照亮了高效无金属光催化剂的设计和应用.
    Doi:10.1039/d2Ta04541A

    海关参考信息

    专利信息


    专利号:US-2010286211-A1
    优先权日:2004-10-08
    标题:Oxazolidinone derivatives as antimicrobials
    发明人:DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
    权利人:DAS BISWAJIT; AHMED SHAHADAL; YADAV AJAY SINGH; GHOSH SOMA; GUJRATI ARTI; SHARMA PANKAJ; RATTAN ASHOK
    摘要:The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, for example, multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, for example, Bacterioides spp. and Clostridia spp. species, and acid fast organisms, for example, Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    专利号:WO-2005082899-A1
    优先权日:2004-01-28
    标 题:Oxazolidinone derivatives as antimicrobials
    发明人:SALMAN MOHAMMAD; BISWAJIT DAS; RUDRA SONALI; YADAV AJAY SINGH; RATTAN ASHOK
    权利人:RANBAXY LAB LTD; SALMAN MOHAMMAD; BISWAJIT DAS; RUDRA SONALI; YADAV AJAY SINGH; RATTAN ASHOK
    摘要:The present invention relates to certain substituted phenyl oxazolidinones of formula (I) and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing such compounds as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

    专利号:CN-105543886-A
    优先权日:2015-12-17
    标 题:Electrochemical Catalytic Synthesis of Aromatic Nitriles

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题: Oxazolidinone Derivatives As Antimicrobials Derives D'Oxazolidinone Utilises Comme Agents Antimicrobiens
    摘要:The Present Invention Relates To Certain Substituted Phenyl Oxazolidinones And To Processes For The Synthesis Of The Same. This Invention Also Relates To Pharmaceutical Compositions Containing The Compounds Of The Present Invention As Antimicrobials. The Compounds Are Useful Antimicrobial Agents, Effective Against A Number Of Human And Veterinary Pathogens, Including Gram-Positive Aerobic Bacteria, For Example, Multiple-Resistant Staphylococci, Streptococci And Enterococci As Well As Anaerobic Organisms, For Example, Bacterioides Spp. And Clostridia Spp. Species, And Acid Fast Organisms, For Example, Mycobacterium Tuberculosis, Mycobacterium Avium And Mycobacterium Spp.

    合成参考文献


    参考文献:10.1055/s-0030-1261181
    摘要:Augustine J, Bombrun A, Atta R. A Practical and Cost-Efficient, One-Pot Conversion of Aldehydes into Nitriles Mediated by ‘Activated DMSO’. Synlett. 2011 Aug 12;2011(15):2223–7. doi: 10.1055/s-0030-1261181.
    参考文献:10.1007/7081_2024_72
    摘要:Das J, Chattopadhyay B. Ir-Catalyzed Borylation of Heterocycles Through C−H Activation. 2024. In: Topics in Heterocyclic Chemistry.
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