CAS: 2154-68-9; 3-Carboxy-2,2,5,5-Tetramethyl-1-Pyrrolidinyloxy

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96623-58-4 1020718-52-8 76193-99-2

上下游产品

3-bromo-2,2,6,6-tetramethyl-1-oxyl-piperidine-4-one 3‐methoxycarbonyl‐2,2,5,5‐tetramethyl‐pyrrolidine‐1‐oxyl 1-hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine cortisol 21-(2,2,5,5-tetramethylpyrrolidin-1-yloxy)-3-carboxylate testosterone 17-(2,2,5,5-tetramethylpyrrolidin-1-yloxyl)-3-carboxylate 3-(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidinyl-1-oxy 3-chloroformyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl

📜3-Bromo-4-Oxo-2,2,6,6-Tetramethylpiperidine 1-Oxyl置于氢氧化钾体系中,化学反应 2.0H,以77%的收率获得3-羧基-Proxyl
参考文献:A Study Of The Favorskii Rearrangement With 3-Bromo-4-Oxo-2,2,6,6-Tetramethylpiperidine-1-Oxyl
标题:A Study Of The Favorskii Rearrangement With 3-Bromo-4-Oxo-2,2,6,6-Tetramethylpiperidine-1-Oxyl
摘要:Favorskii Rearrangement Reactions Of The Title Compound With Sodium Hydroxide,Sodium Ethoxide,Ammonia,Several Aliphatic Amines,And Ethyl Sodiomalonate Resulting In Pyrrolidine Nitroxyl Radicals Are Described.
Doi:10.1021/jo00116A029

专利信息

专利号:US-11359004-B2
优先权日:2012-04-03
标 题:Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins
发明人：VANDEGRIFF KIM D; MALAVALLI ASHOK; MKRTCHYAN GNEL
权利人:SCHINDLER WILLIAM
摘要:The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates to the use of succinimide-activated nitroxyl compounds to prepare nitroxylated proteins, for example nitroxylated heme proteins (e.g., nitroxylated hemoglobin and nitroxylated myoglobin). The nitroxylated proteins are optionally also conjugated to a polyalkylene oxide (PAO), for example to a polyethylene glycol (PEG). Polynitroxylated heme proteins are useful as oxygen therapeutic agents (OTAs). The invention further relates to pharmaceutical compositions of the nitroxylated proteins and methods for the use of nitroxylated proteins in the treatment of various conditions.

专利号:US-2005148042-A1
优先权日:2002-03-29
标 题 :Hybrid phosphoinositide phospholipids: compositions and uses
发明人：PRESTWICH GLENN; RZEPECKI PIOTR W; FERGUSON COLIN G; NEILSEN PAUL O; BRANCH ANGIE M; CROSBY LEE R
摘要:The methods and compositions disclosed herein concern the synthesis of a novel class of “two-headedâ€? phospholipid-phosphoinositide hybrids possessing a carbon backbone, such as 2,3-diacylthreitol, erythritol or a synthetic module. The second phospholipid head group allows introduction of a biochemical or chemical moiety in a position orthogonal in space to those occupied by the phosphoinositide head group and the two acyl chains. The diacyl moieties allow for the incorporation of Pea-PIP 2 into a lipid bilayer, while the Ptdlns(4,5)P 2 moiety in the aqueous layer is specifically recognized by lipid binding proteins. In alternative embodiments of the invention, reporters, for example biotin, fluorophores and/or spin labels, are attached to the free amino group of the head groups of such molecules to specifically target the reporters to the lipid-water interface.

专利号:EP-1756190-B1
优先权日:2004-04-14
标 题:Radically curable resin compositions
发明人：JANSEN JOHAN FRANZ GRADUS ANTO; DRIESSEN MARCO MARCUS MATHEUS; VAN DIJCK MICHAEL ALPHONSUS CO
权利人:DSM IP ASSETS BV
摘要:The present invention relates to resin compositions for radical curing comprising a component (I) containing reactive carbon-carbon unsaturations and a component (II) containing XH-groups, with X not being C or O., which resin compositions (a) are substantially free of photoinitiators; (b.) have an average number of reactive carbon-carbon unsaturations of component (I) equal to or higher than 2; (c) have an average number of XH-groups of component (II) equal to or higher than 2; (d) whereby at least one of the average numbers of (b) and (c) is higher than 2; (e) and at most 5 mol% of the reactive unsaturations is capable of undergoing homopolymerisation; (f) respectively is present in the form of a mono-ene functional alkylene; and (g) the molar ratio of the XH-groups and of the reactive unsaturations is in the range of from 4 : 1 to 1 : 4. The present invention also relates to processes for curing such resin compositions, in particular by cold curing. And finally, the present invention also relates to a new process for the synthesis of Diels-Alder adducts of cyclopentadiene and a resin component containing telechelic carbon-carbon unsaturation. The resin compositions are capable of providing constructive materials with tack-free surfaces by fast, and tunable, radical curing, and without any problems of so-called oxygen inhibition. Suitable applications are in chemical anchoring, roofing, flooring, (re)-lining, SMCs and BMCs.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:WO-2024237180-A1
优先权日:2023-05-16
标题 :(meth)acrylate compound production method
发明人：NAKAKURA KOKI; SHIRAI SHINYOU
权利人:MITSUBISHI GAS CHEMICAL CO
摘要:The present invention provides, inter alia, a (meth)acrylate compound production method capable of suppressing polymerization of a feedstock acrylic acid ester at the time of synthesis and obtaining a reaction product having higher purity. The (meth)acrylate compound production method according to the present invention is characterized by comprising at least a step for carrying out an ester exchange reaction of spiroglycol and a (meth)acrylic acid ester in the presence of a polymerization inhibitor, the polymerization inhibitor containing an N-oxyl compound and a polymerization inhibitor having a boiling point of 246°C or less.