CAS: 20816-79-9; 1-Bromo-8-Chloronaphthalene

相似化合物

325956-47-6 51671-06-8 53220-82-9

1,8-二氨基萘置于盐酸,亚硝酸丁酯,水,铜,对甲苯磺酸,溶剂黄146,Copper(I) Bromide,Sodium Nitrite体系中,用 乙醇,水 用作溶剂,化学反应 27.0H,反应生成1-溴-8-氯萘
参考文献: Covalent Ras Inhibitors And Uses Thereof[fr] Inhibiteurs De Ras Covalents Et Leurs Utilisations
标题: Covalent Ras Inhibitors And Uses Thereof[fr] Inhibiteurs De Ras Covalents Et Leurs Utilisations
摘要:该披露涵盖化合物或其药用盐,单独或与其他治疗剂,药物组合和蛋白共轭物结合在一起,能够调节包括ras在内的生物过程,并在癌症治疗中的用途.

专利信息

专利号:WO-2007147775-A1
优先权日:2006-06-20
标 题 :Process for synthesis of aromatic compounds
发明人：HUTCHINGS MICHAEL GORDON; QUAYLE PETER; BULL JAMES ALAN; BARROSO CRISTINA LUJAN
权利人:DYSTAR TEXTILFARBEN GMBH & CO; HUTCHINGS MICHAEL GORDON; QUAYLE PETER; BULL JAMES ALAN; BARROSO CRISTINA LUJAN
摘要:The present invention refers to a process for preparing a compound of the formula (I) wherein R denotes an organic radical which, together with the two carbon atoms to which it is bonded, forms a carbocyclic or heterocyclic ring; R1, R2, R3 and X, independently, denote hydrogen, halogen, nitro, cyano or an organic radical; or R1 and R2 or R2 and R3, together with the carbon atoms to which they are bonded, form a ring; which comprises exposing a compound of the formula (II) wherein R1, R2, R3 and X are defined as given above and Y and Z, independently, have one of the meanings of X; to an energy source in the presence of a catalyst system.

专利号:US-2024400558-A1
优先权日:2021-09-09
标题 :Processes and intermediates for synthesis of adagrasib
发明人：SCATTOLIN THOMAS; CHEN CHENG; GHARBAOUI TAWFIK; GAN YONGHONG; ACHMATOWICZ MICHAL; SNEAD DAVID
权利人:MIRATI THERAPEUTICS INC
摘要:The present invention relates to improved synthetic routes of synthesizing adagrasib. The invention also provides intermediates used in the provided synthetic routes.

专利号:CN-119039289-A
优先权日:2024-07-30
标 题 :A novel intermediate for the synthesis of Adalagesibu and its preparation method