CAS: 206060-54-0; (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(4-Hydroxy-2,6-Dimethylphenyl)Propanoic Acid

相似化合物

123715-02-6 2108806-15-9 126312-63-8

上下游产品

N-Boc-2,6-二甲基-L-酪氨酸 (S)-N-Boc-2,6-Dimethyltyrosine 99953-00-1
氯甲酸-9-芴基甲酯 (Fluorenylmethoxy)Carbonyl Chloride 28920-43-6
9-芴甲基-N-琥珀酰亚胺基碳酸酯 N-(9H-Fluoren-2-Ylmethoxycarbonyloxy)Succinimide 82911-69-1

N-Boc-2,6-二甲基-L-酪氨酸置于盐酸,Sodium Carbonate体系中,用 二氯甲烷,水,丙酮 用作溶剂,化学反应 15.0H,反应生成N-芴甲氧羰基-2,6-二甲基-L-酪氨酸
参考文献:固相偶氮肽diels-Al杂化学用于合成氮杂哌啶基残基以研究肽的构象
标题:固相偶氮肽diels-Al杂化学用于合成氮杂哌啶基残基以研究肽的构象
摘要:用于fmoc保护的偶氮肽的合成和diels-Alder反应的固相化学已得到开发,并用于构建氮杂-哌啶基(azapip)肽.考虑到它们在模型肽中诱导有利于顺式酰胺异构体几何形状和vi型β-转角构象的电子和结构限制的能力,现在已经通过这种可行的合成方法将azapip残基引入生物学相关的靶标中.通过使用azapip残基研究阿片类药物的构象要求和分化的36种受体肽配体簇,证明了转角构象异构体对于受体亲和力,选择性和活性很重要.
Doi:10.1021/acs.Joc.8B03283

专利信息

专利号:US-7759514-B2
优先权日:2002-10-11
标题:Mu opioid receptor ligands: methods of use and synthesis
发明人：HARRISON BRYCE A; GIERASCH TIFFANY MALINKY; VERDINE GREGORY L; SHI ZHANGJIE
权利人:HARRISON BRYCE A; GIERASCH TIFFANY MALINKY; VERDINE GREGORY L; SHI ZHANGJIE
摘要:Novel compounds and compositions including those compounds, as well as methods of using and making the compounds are herein described. The compounds are useful in therapeutic applications, including modulation of disease or disease symptoms in a subject (e.g., mammal, human, dog, cat, horse). The compounds are useful as modulators of the mu opioid receptor (MOR) through their binding affinity with that receptor.

专利号:US-2004254225-A1
优先权日:2002-10-11
标题 :Mu opioid receptor ligands: methods of use and synthesis

专利号:US-7223888-B2
优先权日:2002-10-11
标 题 :Mu opioid receptor ligands: methods of use and synthesis

专利号:US-2009093534-A1
优先权日:2002-10-11
标 题:Mu opioid receptor ligands: methods of use and synthesis

专利号:WO-2004033414-A1
优先权日:2002-10-11
标题 :Mu opioid receptor ligands: methods of use and synthesis