CAS: 1883-13-2; 3-Hydroxydodecanoic Acid

相似化合物

1961-72-4 14292-26-3 14292-27-4

上下游产品

methyl 3-oxododecanoate caprinaldehyde ethyl bromoacetate tert-butyl esterbromoacetic acid tert-butyl ester 2-methyldecanal 2-Tetradecyl-hexadecanoic acid (2R,3R,4R,5S,6R)-2-benzyloxy-6-benzyloxymethoxymethyl-5-(diphenoxy-phosphoryloxy)-3-(3-hydroxy-dodecanoylamino)-tetrahydro-pyran-4-yl ester β-hydroxydodecanoic acid methyl ester N-(3-hydroxy-dodecanoyl)-L-homoserine lactone

📜癸醛置于tetrabutylammonium Borohydride,Tin(Ll) Chloride,Sodium Hydroxide体系中,用 甲醇,二氯甲烷,水,溶剂黄146 用作溶剂,化学反应 26.0H,反应生成3-羟基月桂 酸
参考文献:连续的荧光sirtuin 2脱酰基酶测定:底物筛选和抑制剂评估
标题:连续的荧光sirtuin 2脱酰基酶测定:底物筛选和抑制剂评估
摘要:Sirtuins是赖氨酸酰化的重要调节剂,其与细胞代谢和转录控制有关.这使得sirtuin类酶成为开发具有药物潜力的小分子探针的有趣靶标.为了获得有关瑟土因抑制剂的详细分析和动力学见解,重要的是要获得有效的测定方法.在这项工作中,我们报告了易于合成的荧光底物,能够以连续测定形式对sirt2抑制剂进行酶经济评价,以及对sirt2作为长链脱酰基酶的特性进行评价.因此,在体外建立了sirt2的新酶活性,需要进一步研究,并且针对含有ε-N的底物分析了两种已知的抑制剂,苏拉明和sirreal2.-不同长度的酰基赖氨酸修饰.
Doi:10.1021/acs.Jmedchem.5B01532

专利信息

专利号:US-2024392331-A1
优先权日:2023-05-23
标题:Engineered Microorganisms For Synthesis Of Polyhydroxyalkanoates
发明人：CHARLES TREVOR; CHENG JIUJUN; THAKOR ARANKSHA; LEBLANC NICOLE
权利人:CHARLES TREVOR; CHENG JIUJUN; THAKOR ARANKSHA; LEBLANC NICOLE
摘要:A genetically engineered strain of Pseudomonas is provided, which is capable of metabolizing lactose as a sole carbon source in the production of polyhydroxyalkanoates (PHAs). A method of engineering microorganisms and a method of PHA production are also provided, wherein lactose is used as a sole carbon source.

专利号:US-6600029-B1
优先权日:1995-12-19
标题:Metabolic engineering of polyhydroxyalkanoate monomer synthases
发明人：SHERMAN DAVID H; WILLIAMS MARK D; XUE YONGQUAN
权利人:UNIV MINNESOTA
摘要:A novel pathway for the synthesis of polyhydroxyalkanoate is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalknoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalknoate synthase.

专利号:US-RE37543-E
优先权日:1996-08-13
标 题:DNA sequence useful for the production of polyhydroxyalkanoates
发明人：KRUEGER NIELS; STEINBUECHEL ALEXANDER
权利人:MONSANTO CO
摘要:A genomic fragment harboring the gene phaG was cloned by phenotype complementation of Pseudomonas putida KT2440 mutants, defective in the polyhydroxyalkanoic acid (PHA) synthesis via de novo fatty acid biosynthesis but not affected in PHA biosynthesis via fatty acid beta-oxidation. The 885-bp phaG gene encodes a protein of 295 amino acids with a molecular weight of 33.876 Da. The transcriptional induction of phaG could be observed under conditions of PHA synthesis via de novo fatty acid biosynthesis whereas no induction was detected under conditions which favor PHA synthesis via fatty acid degradation by beta-oxidation. The phaG gene is useful for the production of PHAs in bacteria and plants.

专利号:US-2003194784-A1
优先权日:2001-04-17
标题:DNA encoding methymycin and pikromycin
发明人：SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN
摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.

专利号:US-8563281-B2
优先权日:2008-04-23
标题 :Method for production of polyester copolymer using recombinant microorganism
发明人：TAGUCHI SEIICHI; TAJIMA KENJI; SATOH YASUHARU; MATSUMOTO KEN ICHIRO; YAMADA MIWA; OBATA SHUSEI; KAMBE HIROMI; KOHDA KATSUNORI; OHNO KATSUHIRO; SHIMAMURA TAKASHI
权利人:TAGUCHI SEIICHI; TAJIMA KENJI; SATOH YASUHARU; MATSUMOTO KEN ICHIRO; YAMADA MIWA; OBATA SHUSEI; KAMBE HIROMI; KOHDA KATSUNORI; OHNO KATSUHIRO; SHIMAMURA TAKASHI; TOYOTA MOTOR CO LTD
摘要:The object of the present invention is to provide a method for efficiently producing a polyester copolymer consisting of 3-hydroxybutyrate and lactate via microbial fermentation with the use of a sugar as a starting material. The method may comprise culturing a recombinant microorganism expressing: a protein capable of catalyzing the transfer of CoA to propionic acid and/or lactate; a protein capable of catalyzing the formation of acetoacetyl-CoA from two acetyl-CoA molecules; a protein capable of catalyzing acetoacetyl-CoA reduction; and a protein capable of catalyzing polyhydroxyalkanoate synthesis. According to the production method, a polyester copolymer consisting of 3-hydroxybutyrate and lactate can be efficiently produced using an inexpensive carbon source as a starting material, and thus the production cost of a biodegradable plastic can be reduced.

专利号:US-6103956-A
优先权日:1998-03-31
标题:Polyhydroxyalkanoate synthesis in plants
发明人：SRIENC FRIEDRICH; SOMERS DAVID A; HAHN J J; ESCHENLAUER ARTHUR C
权利人:UNIV MINNESOTA
摘要:Novel transgenic plants and plant cells are capable of biosynthesis of polyhydroxyalkanoate (PHA). Heterologous enzymes involved in PHA biosynthesis, particularly PHA polymerase, are targeted to the peroxisome of a transgenic plant. Transgenic plant materials that biosynthesize short chain length monomer PHAs in the absence of heterologous beta -ketothiolase and acetoacetyl-CoA reductase are also disclosed.