CAS: 18609-16-0; 6-Deacetylnimbin

该化合物是一种天然的三元素化合物,产自neem树(Azadirachta indica),是硝基苯的衍生物,其特点是C1位置没有乙酰组,这种结构改变与其母化合物相比提高了其溶性性和生物利用率.脱乙基尼宾表现出显著的抗炎,抗微生物和杀虫特性,使它成为农业和制药研究的热门.其行动机制包括改变生物化学途径,特别是与虫害控制和免疫反应有关的路径.该化合物因其生态友好特征和在可持续虫害管理和治疗配方中的潜在应用而受到重视.

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上下游产品

diazomethane methanol Nimbin Nimbin

合成工艺路线路线简述

    📜印楝素置于乙二胺体系中,用 甲醇 用作溶剂,化学反应 0.12H,以75%的收率获得脱乙酰基印楝素
    参考文献:Ethylenediamine: An Effective Reagent For Deacetylation Of Natural Products
    标题:Ethylenediamine: An Effective Reagent For Deacetylation Of Natural Products
    摘要:The Use Of Ethylenediamine In Methanol Is Described For The Selective Cleavage Of The Acetate Group In Nimbin (1) To 6-Deacetyl Nimbin (1A) Under Microwave Irradiation. This Method Enables To Deacetylate Without Affecting Other Functional Groups Such As,-Unsaturated Ketone,Ester,Ether,Etc. In Certain Tetranortriterpenoids And Other Acetate-Containing Natural Compounds.
    Doi:10.1080/10286020.2010.507545

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    合成参考文献


    参考文献:10.1021/np50081a005
    摘要:Siddiqui S, Faizi S, Siddiqui BS, Ghiasuddin. Constituents of Azadirachta indica: isolation and structure elucidation of a new antibacterial tetranortriterpenoid, mahmoodin, and a new protolimonoid, naheedin. J Nat Prod. 1992 Mar;55(3):303–10. doi: 10.1021/np50081a005.
    参考文献:10.1002/(sici)1520-6327(1997)35:1/2<199::aid-arch18>3.0.co;2-6|10.1002/(sici)1520-6327(1997)35:1/2<199::aid-arch18>3.3.co;2-7
    摘要:Mitchell MJ, Smith SL, Johnson S, Morgan ED. Effects of the neem tree compounds azadirachtin, salannin, nimbin, and 6-desacetylnimbin on ecdysone 20-monooxygenase activity. Arch Insect Biochem Physiol. 1997;35(1-2):199–209. doi: 10.1002/(sici)1520-6327(1997)35:1/2<199::aid-arch18>3.0.co;2-6.
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