CAS: 158407-04-6; Tert-Butyl 4-(Bromomethyl)Piperidine-1-Carboxylate

相似化合物

1159825-22-5 159275-17-9 98338-26-2

上下游产品

CAS号123855-51-6 N-B°C-4-哌啶甲醇 | CAS号498-94-2 4-哌啶甲酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号84358-13-4 1-B°C-4-哌啶甲酸 | CAS号145508-94-7 1-叔丁氧羰基-4-碘甲基哌啶

📜4-哌啶甲醇置于三苯基膦,Sodium Hydroxide体系中,用 1,4-二氧六环,二氯甲烷,水 用作溶剂,化学反应 1.58H,反应生成1-Boc-4-溴甲基哌啶
参考文献:一类具有tdo,Ido1双重抑制活性的化合物及制备治疗神经退行性疾病药物的用途
标题:一类具有tdo,Ido1双重抑制活性的化合物及制备治疗神经退行性疾病药物的用途
摘要:本发明提供了式i所示的化合物,或其药学上可接受的盐,或其溶剂合物,其可以选择性地抑制tdo,Ido1,其对tdo和/或ido1具有明显的抑制效果.此外,本发明制备的化合物具有明显的抗肿瘤效果,对帕金森病,阿尔茨海默症也有一定治疗作用,其在药物制备领域具有很好的应用前景.

专利信息

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-9249154-B2
优先权日:2008-01-08
标题:Compounds and therapeutic use thereof for protein kinase inhibition
发明人：WU ZHANGGUI
权利人:WU ZHANGGUI
摘要:Novel compound having the following formula: n nAlso disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of the same. The novel compounds of the present invention are found to inhibit protein kinases, especially Checkpoint kinase Chk1/Chk2.

专利号:US-9925177-B2
优先权日:2015-01-22
标题:4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.

专利号:US-11123337-B2
优先权日:2015-01-22
标题 :4-methylsulfonyl-substituted piperidine urea compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; KIM JAE; MCDOWELL ROBERT; SONG YONGHONG; SRAN ARVINDER; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.