CAS: 151259-38-0; Tert-Butyl Diallylcarbamate

相似化合物

50487-72-4 2424-01-3 6147-66-6

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号124-02-7 二烯丙基胺 | CAS号51154-06-4 (S)-1-(叔丁氧羰基)-2... | CAS号73286-70-1 N-B°C-3-吡咯啉 | CAS号114214-49-2 3-N-叔丁氧羰基-6-氧杂-...

📜二碳酸二叔丁酯,二烯丙基胺 以 环己烷 用作溶剂,以93%的收率获得n,N-二烯丙基氨基甲酸叔丁酯
参考文献:Technical Scale Synthesis Of A New And Highly Potent Thrombin Inhibitor
标题:Technical Scale Synthesis Of A New And Highly Potent Thrombin Inhibitor
摘要:在本报告中,我们描述了在生产工厂规模上开发一种高效且收敛的肽类模仿物 Thrombin 抑制剂 1 的过程.以尼古丁腈(13),(2S,4R)-1-(叔丁氧基碳酰基)-4-羟基-2-吡咯烷羧酸(5)和 (2R)-2-氨基-3-环己基丙酸(29)为起始材料,通过16个化学步骤合成出了化合物 1.我们开发了新方法以制备关键中间体去氢脯氨酸 22,并将腈转化为酰胺.通过特殊技术(纳滤和喷雾干燥)分离得到了 Thrombin 抑制剂 1.几乎所有的 1 的盐都是无定形的,然而,我们得到了一种与 1,2-苯异噻唑-3(2H)-酮 1,1-二氧化物(糖精®)的结晶复合物.
Doi:10.1055/s-2004-831200

专利信息

专利号:US-6417363-B1
优先权日:1997-12-04
标题 :Heterocyclyl ligand containing ruthenium and osmium catalysts
发明人：VAN DER SCHAAF PAUL ADRIAAN; MUEHLEBACH ANDREAS; HAFNER ANDREAS; KOLLY ROMAN
权利人:CIBA SC HOLDING AG
摘要:Penta- and hexa-coordinated, bridged ruthenium and osmium catalysts of the formulawherein Me is ruthenium or osmium; L1 and L2 are neutral ligands having electron donor properties;X is an anionic ligand; Y is oxygen or sulphur; A is a direct bond, C1-C4alkylene or C2-C4alkylidene;Z is a direct bond, oxygen, sulphur or the groupswherein R1 and R2 are hydrogen or hydrocarbon radicals; their preparation and their us in the synthesis of polymers, in the ring-closure metathesis of diolefins, in the cross metathesis of olefins and in the isomerisation of olefins are disclosed.

专利号:CN-103193781-B
优先权日:2013-04-01
标题 :A specific inhibitor compound of SAHN enzyme protein and its synthesis method

专利号:CN-103193781-A
优先权日:2013-04-01
标 题 :A specific inhibitor compound of SAHN enzyme protein and its synthesis method