CAS: 14432-12-3; 4-Amino-2-Chloropyridine

相似化合物

234108-73-7 23056-36-2 2587-02-2

上下游产品

2,4-dichloropyridine 2-chloro-4-nitropyridine-N-oxide 2-chloroisonicotinoyl azide 2-chloro-4-nitropyridine 2-chloro-4-pyridinenitrile 2,4-dichloropyridine 2-chloro-4-bromopyridine 2-chloro-4-iodopyridine

2-氯吡啶-N-氧化物置于盐酸,硫酸,硝酸,铁粉体系中,用 乙醇,水 用作溶剂,化学反应生成2-氯-4-氨基吡啶
参考文献:设计和合成嘌呤类似物作为fcγb(一种无处不在的真菌核碱基转运蛋白)的高度特异性配体
标题:设计和合成嘌呤类似物作为fcγb(一种无处不在的真菌核碱基转运蛋白)的高度特异性配体
摘要:在我们对真菌嘌呤转运蛋白的研究过程中,基于嘌呤底物与构巢曲霉fcγb载体的相互作用,合理地设计了许多新的3-脱氮嘌呤类似物,并按照有效的合成程序进行了合成.已经发现某些衍生物特异性抑制fcγb介导的[ 3 H]-腺嘌呤摄取.已经进行了分子模拟,表明所有活性化合物都通过与asn163形成氢键与fcyb相互作用,而在3-Deazaadenine的9和n 6位插入疏水片段增强了抑制作用.
Doi:10.1016/j.Bmc.2016.09.055

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-9751851-B2
优先权日:2013-09-20
标 题:Molecules and compositions that inhibit gram negative bacteria and their uses
发明人：BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T
权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T
摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.

专利号:US-10000487-B2
优先权日:2015-11-20
标 题 :Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
发明人：SPRENGELER PAUL A; REICH SEIGFRIED H; WEBBER STEPHEN E; ERNST JUSTIN T
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula IA or Formula IB, as well as stereoisomers, tautomers or pharmaceutically acceptable salts thereof. n nFor Formula IA and Formula IB compounds A 1 , A 2 , A 3 , A 4 , W 1 , W 2 , Y, X, R 1 , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b , R 6 , R 7 , R 8 , R 9 , R 9a , R 9b , R 10 and subscript n are as defined in the specification. The inventive Formula IA and Formula IB compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-7999090-B2
优先权日:2000-07-07
标 题:Fungal cell wall synthesis gene
发明人：TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO
权利人:EISAI R&D MAN CO LTD
摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.

专利号:CN-104262242-B
优先权日:2014-09-22
标题 :Synthesis of 3,5-diiodo-4-aminopyridine by in situ generation of iodo reagent

专利号:CN-104262242-A
优先权日:2014-09-22
标 题:Synthesis of 3,5-diiodo-4-aminopyridine by in situ generation of iodo reagent