CAS: 1318794-28-3; (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(((4-Ethoxybenzyl)Oxy)Methyl)Phenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

英文名称(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(((4-Ethoxybenzyl)Oxy)Methyl)Phenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
中文名称达格列净杂质5
IUPAC名称(2S,3R,4R,5S,6R)-2-(4-chloro-3-(((4-ethoxybenzyl)oxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
其它别名Dapagliflozin Impurity 38; Dapagliflozin Impurity 15/(2S,3R,4R,5S,6R)-2-(4-Chloro-3-((4-Ethoxyphenyl)(Methoxy) Methyl)Phenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol; Dapagliflozin-4; Dapagliflozin Impurity 96; D-Glucitol, 1,5-Anhydro-1-C-[4-Chloro-3-[(4-Ethoxyphenyl)Methoxymethyl]Phenyl]-, (1S)-; (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(((4-Ethoxybenzyl)Oxy)Methyl)Phenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol; (2S,3R,4R,5S,6R)-2-(4-Chloro-3-((4-Ethoxyphenyl)(Methoxy) Methyl)Phenyl)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol
CAS编号1318794-28-3
FDA UNII编号:34FB7R7U3Z
分子式:C22H27ClO7分子量:438.9
产品CID: 485436
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: GXBOAGPWTHGVSS-BDHVOXNPSA-N
InChI=1S/C22H27ClO7/c1-2-29-16-6-3-13(4-7-16)11-28-12-15-9-14(5-8-17(15)23)22-21(27)20(26)19(25)18(10-24)30-22/h3-9,18-22,24-27H,2,10-12H2,1H3/t18-,19-,20+,21-,22+/m1/s1
计算化学: 氢键受体数7.0氢键供体数4.0可旋转键数7.0

物理性质

MSDS等安全信息

上下游产品

5-bromo-2-chlorobenzoic acid 5-bromo-2-chloro-benzoyl chloride (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol

合成工艺路线路线简述

📜Methyl 1-{4-Chloro-3-[1-(4-Ethyloxyphenyl)(Methoxy)Methyl]Phenyl}-α/β-D-Glucopyranoside置于甲醇,三乙基硅烷,三氟化硼乙醚,Sodium Methylate,Sodium Acetate体系中,用二氯甲烷用作溶剂,化学反应 6.0H,反应生成达格列净杂质5
参考文献:Phenyl C-Glucoside Derivatives,Preparation Methods And Uses Thereof
标题:Phenyl C-Glucoside Derivatives,Preparation Methods And Uses Thereof
摘要:该发明涉及一种具有苯基c-葡萄苷结构的钠葡萄糖共转运蛋白2(sglt2)抑制剂,其制备方法,含有该抑制剂的药物组合物,以及其在治疗糖尿病和制备抗糖尿病药物中的用途.该发明提供了一种具有一般式i结构的化合物及其药用盐和前药酯,其中,R5和r6的定义从以下选定:(1)r5=r6=me;(2)r5=me,R6=ome;(3)r5=me,R6=h;(4)r5=me,R6=f;(5)r5=f,R6=h;和(6)r5=ome,R6=h.