CAS: 125472-02-8; Mivazerol

上下游产品

Methyl 2-Hydroxy-3-[(1H-Imidazol-4-yl)Methyl]-Benzoate 127171-02-2
2-Hydroxy-3-[(1H-Imidazol-4-yl)Methyl]-Benzonitrile 127171-22-6

📜2-Hydroxy-3-[(1H-Imidazol-4-yl)Methyl]-Benzonitrile置于sodium Chloride,硫酸体系中,用68%的收率获得米伐折醇
参考文献:Substituted 1-(1H-Imidazol-4-yl)Alkyl-Benzamides As Anti-Ischemics And
标题:Substituted 1-(1H-Imidazol-4-yl)Alkyl-Benzamides As Anti-Ischemics And
摘要:新的取代1-(1H-咪唑-4-基)烷基苯甲酰胺及其盐,其制备方法和药物组合物.这些化合物的化学式为##str1##其中r.Sub.1,R.Sub.2 =氢或c.Sub.1-C.Sub.4-烷基,R.Sub.3 =氢,氨基,羟基,C.Sub.1-C.Sub.4-烷基或c.Sub.1-C.Sub.4-羟基烷基,R.Sub.4 =氢或c.Sub.1-C.Sub.4-烷基,或r.Sub.3 R.Sub.4 N=吡咯啉基,哌啶基或吗啉基,R.Sub.5和r.Sub.6 =氢,羟基,C.Sub.1-C.Sub.4-烷基或c.Sub.1-C.Sub.4-烷氧基,R.Sub.5和r.Sub.6中至少一个不是氢.这些化合物可以通过将氮化合物与烷基1-(1H-咪唑-4-基)烷基苯甲酸酯或1-(1H-咪唑-4-基)烷基苯甲酸反应,或者在酸性介质中水解2-羟基-3-[1-(1H-咪唑-4-基)烷基]-苯甲腈来制备.这些化合物具有抗缺血和α2-肾上腺素受体激动剂活性.

专利信息

专利号:US-2022089618-A1
优先权日:2019-01-29
标题:Solid-State Synthesis Of Precursors Of Metal-Organic Frameworks
发明人：MAJANO GERARDO J; FALKOWSKI JOSEPH M
权利人:EXXONMOBIL RES & ENG CO
摘要:Metal-organic frameworks (MOFs) are highly porous entities comprising a multidentate ligand coordinated to multiple metal atoms, typically as a coordination polymer. MOFs are usually produced from a solvent in powder form under hydrothermal or solvothermal synthesis conditions. Alternately, powder-form precursors of MOFs may be formed by milling or mulling a substantially solid mixture of a metal salt and a multidentate organic ligand, optionally in the presence of a small amount of a solvent. The powder-form precursors may then undergo heating, typically in the absence of applied shear, to produce the corresponding MOF. Mulling may be differentiated from milling at least in that mulling applies to the substantially solid mixture at a non-constant pressure and milling applies a constant pressure while forming the powder-form precursor. In some cases, mulling may promote more effective formation of the powder-form precursor compared to milling.

专利号:US-2009318592-A1
优先权日:2005-10-11
标 题 :Process for the Synthesis of Amine Ethers
发明人：FREY MARKUS; BROENNIMANN VALERIE
权利人:CIBA GEIGY CORP
摘要:The present invention relates to novel processes for the preparation of a sterically hindered amine ether by reacting a corresponding sterically hindered amine oxide with a ketone or an aldehyde with at least one reactive H in the presence of a peroxydisulphate. Products obtained by this process may be hydrogenated. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.

专利号:US-2025011531-A1
优先权日:2020-06-25
标 题:Synthesis of environmentally degradable alkyl polyesters
发明人：PARK KINAM; GARNER JOHN SOLOMON
权利人:AKINA INC
摘要:A solid crosslinked polyester composition that is environmentally degradable in less than about 180 days. The crosslinked polyester can be the polyesterification reaction product between one or more multi-hydroxylic alcohols, one or more hydroxy acids, and one or more multi-carboxylic acid compounds. Alternately, the crosslinked polyester can be the polyesterification reaction product of one or more multi-hydroxylic alcohols, one or more hydroxy acids, one or more multi-carboxylic acid compounds, and a cyclic ester. Provided, however that if the one or more hydroxy acids has only one carboxyl group, it has two or more hydroxyl groups, and if the one or more hydroxy acids has only one hydroxyl group, it has two or more carboxyl groups.

专利号:US-2007191516-A1
优先权日:2004-03-15
标题 :Process for the synthesis of amine ethers
发明人：FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS
权利人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS
摘要:A process for the preparation of a sterically hindered amine ether which comprises reacting a corresponding sterically hindered aminoxide with a C 5 -C 18 alk-1-ene in the presence of an organic hydroperoxide and optionally hydrogenating the resulting product as well as the product mixtures obtained therewith and their use as stabilizers and flame retardants.

专利号:US-8865854-B2
优先权日:2010-01-07
标 题:Method of synthesizing tuneably high functionality in high molecular weight natural oil polyols
发明人：GARRETT THOMAS M; DU XIAN XIAN
权利人:GARRETT THOMAS M; DU XIAN XIAN
摘要:Methods of one-pot synthesis of high molecular weight natural oil polyols having a functionality of between about 4 and about 8 are provided. The resultant polyols may be directly reacted with polyisocyanates to produce polyurethanes.

专利号:US-7402675-B2
优先权日:2000-05-26
标题 :Process for the synthesis of amine ethers from secondary amino oxides
发明人：HAFNER ANDREAS; KIRNER HANS JUERG; SCHWARZENBACH FRANZ; VAN DER SCHAAF PAUL ADRIAAN; NESVADBA PETER
权利人:CIBA SC HOLDING AG
摘要:An amine ether of formula A n nwherein a is 1 or 2; and when a is 1, E is E′; when a is 2, E is L;n E′ is C 1 -C 36 alkyl; C 3 -C 18 alkenyl; C 2 -C 18 alkinyl; C 5 -C 18 cycloalkyl; C 5 -C 18 cycloalkenyl; a radical of a saturated or unsaturated aliphatic bicyclic or tricyclic hydrocarbon of 7 to 12 carbon atoms; C 2 -C 7 alkyl or C 3 -C 7 alkenyl substituted by halogen; C 7 -C 15 aralkyl or C 7 -C 15 aralkyl substituted by C 1 -C 4 alkyl or phenyl; or E′ is a radical of formula (VII) as explained in claim 1; T′ is tertiary C 4 -C 18 alkyl or phenyl, each of which are unsubstituted or substituted by halogen, OH, COOR 21 or C(O)—R 22 ; or T′ is C 5 -C 12 cycloalkyl; C 5 -C 12 cycloalkyl which is interrupted by at least one O or —NR 18 —; a polycyclic alkyl radical having 7-18 carbon atoms, or the same radical which is interrupted by at least one O or —NR 18 —; or T′ is —C(G 1 )(G 2 )-T″; or C 1 -C 18 alkyl or C 5 -C 12 cycloalkyl substituted by n n n n n n n n n n n n T″ is hydrogen, halogen, NO 2 , cyano, or is a monovalent organic radical comprising 1-50 carbon atoms; n or T″ and T′ together form a divalent organic linking group completing, together with the hindered amine nitrogen atom and the quaternary carbon atom substituted by G 1 and G 2 , an optionally substituted five- or six-membered ring structure; and all other residues are as defined in claim 1, n are obtained in good yield from the corresponding N-oxyl hindered amine precursor by reaction with a hydrocarbon E 1 -H or H-L-H in the presence of an organic hydroperoxide and a catalytic amount of copper or a copper compound. n n n n n The products of present process find utility as polymerization regulators and/or light stabilizers for organic material.