CAS: 1189-11-3; (S)-2-Amino-5-(3-Phosphonoguanidino)Pentanoic Acid

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CAS号74-79-3 L-精氨酸 | CAS号74-79-3 L-精氨酸 | CAS号7664-38-2 磷酸

📜L-精氨酸置于potassium Monophosphoramidate体系中,用 水 用作溶剂,化学反应 48.0H,反应生成磷酸精胺酸
参考文献:硫代磷酰胺酸根离子对游离氨基酸和酶蛋白的硫代磷酸化
标题:硫代磷酰胺酸根离子对游离氨基酸和酶蛋白的硫代磷酸化
摘要:为了寻找保持活性的蛋白质硫代磷酸化方法,以胸苷酸合酶重组蛋白为底物,在基于tris和碳酸铵的缓冲溶液中使用了硫代磷酸氨基钾钾和硫代磷酸氨基二铵盐,事实证明可以用作无损环境.使用氨基磷酸钾或硫代磷酸氨基二铵制备了一系列磷酸化和硫代磷酸化的氨基酸衍生物,并与31 P NMR化学位移的计算(使用密度泛函理论,Dft)估计一起,帮助确定了硫代磷酸化蛋白的NMR共振并证明了其存在.硫代磷酸化的赖氨酸,丝氨酸和组氨酸部分.对31个预测有用的方法还介绍了硫代磷酸化的氨基酸部分和通常的硫代磷酸酯的1 H NMR化学位移.从胰蛋白酶消化酶获得的初步结果显示,峰位于m / Z 1825.805,与tvqqqvhlnqdeyk的单硫代磷酸酯的模拟同位素模式分布完全吻合,其中硫代磷酸酯部分连接至组氨酸(his 26)或赖氨酸(lys 33)侧.链.
Doi:10.1016/j.Bioorg.2009.11.002

专利信息

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:EP-0150883-B1
优先权日:1984-02-02
标题 :Process for preparing n-(dibenzyloxyphosphoryl)-cyanamide and processes using said compounds as intermediate for the synthesis of phosphagen substances
摘要:The invention relates to a process for preparing compounds of general formula: wherein R = Hydrogen, halogen, alkyl, nitro-group; said compounds, which are indicated hereinunder with the general term <> are useful as intermediates in the synthesis of phosphagen compounds such as phosphocreatine, phosphocreatinine and similar compounds. Such process is characterized in that dibenzyloxyphosphoryl chloride is reacted with cyanamide, N-(dibenzyloxyphosphoryl)-cyanamide being produced; this latter can react with substances provided with a primary or secondary amine function, to give the corresponding guanidinoderivatives; e.g., with a sarcosine derivative to give N-(dibenzyloxyphosphoryl)-creatine or N-(dibenzyloxyphosphoryl)-creatinine.

专利号:US-4307192-A
优先权日:1979-05-17
标题:Cell-free synthesis of deacetoxycephalosporin C
发明人：DEMAIN ARNOLD L; KONOMI TOSHIO; BALDWIN JACK E
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A cell-free process for converting isopenicillin N, δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (hereinafter 'LLD') and 6-substituted derivatives thereof to deacetoxycephalosporin C (DACPC) by the following reaction sequence: ##STR1## is disclosed. In addition to the starting material, the reaction system includes ATP and a fresh extract of Cephalosporium acremonium prepared and used in a manner to preserve the racemase agent or agents necessary for conversion of the isopenicillin N to penicillin N, a necessary intermediate step in the process.

专利号:US-4178210-A
优先权日:1977-03-07
标 题:Accellular synthesis of cephalosporins
发明人：DEMAIN ARNOLD L; KOHSAKA MASANOBU
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A cephalosporin antibiotic is produced from a precursor comprising the five membered thiazolidine ring and the beta lactam moiety characteristics of penicillins by contacting the precursor with a cell-free extract of Cephalosporium acremonium in the presence of ATP under conditions favoring high oxygen transfer. Preferably, an ATP regeneration system comprising a phosphate donor and a phosphotransferase enzyme is included in the reaction.

专利号:US-5780039-A
优先权日:1992-04-23
标 题:Orally-ingestible nutrition compositions having improved palatability
发明人：GREENBERG NORMAN A; KVAMME CANDIS; SCHMIDL MARY K
权利人:NOVARTIS NUTRITION AG
摘要:An orally-ingestible nutrition composition having improved taste comprises a low pH (<7.0) form of an amino acid selected from arginine, valine and compounds associated with the synthesis of polyamines. Preferred low pH forms are salts such as arginine phosphate and mixtures thereof with arginine citrate. Preferred nutrition composition also comprise encapsulated polyunsaturated fatty acid.

专利号:US-2009209032-A1
优先权日:2004-10-01
标 题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules