合成目标产物 Dimethyl Glutarate 主要起始原料 Methanol And Glutaric Anhydride
(文献来源)合成步骤主要原料 Methanol 和 Glutaric Anhydride
戊二酸单甲酯置于氯化亚砜,溴体系中,化学反应 17.0H,反应生成戊二酸二甲酯 参考文献:Preparation And Diels-Alder Reactions Of 1,1-Dicarbonylalkenes 标题:Preparation And Diels-Alder Reactions Of 1,1-Dicarbonylalkenes 摘要: Doi:10.1021/jo00142A028
专利号:US-4092351-A 优先权日:1976-02-17 标 题 :Method of synthesis of 4,5,6-trihydroxyisophthalic acid 发明人:SHIPCHANDLER MOHAMMED T 权利人:IMC CHEMICAL GROUP 摘要:A process for the synthesis of 4,5,6-trihydroxyisophthalic acid by reacting dialkyl glutarate with dialkyl dialkoxymalonate.
专利号:US-4046817-A 优先权日:1974-07-19 标题 :Method of synthesis of pyrogallol 发明人:SHIPCHANDLER MOHAMMED T 权利人:IMC CHEMICAL GROUP 摘要:A process for the synthesis of pyrogallol from glutaric ester and dialkoxymalonic ester.
专利号:US-2024082118-A1 优先权日:2021-05-19 标 题:Topical compositions and methods of preparing the same 发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION 权利人:LANDA LABS 2012 LTD 摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-2010055750-A1 优先权日:2008-09-03 标 题:Polyester synthesis 发明人:WOSNICK JORDAN H 权利人:XEROX CORP 摘要:The present disclosure provides for enzymatic polymerization to produce polyester resins suitable for use in manufacturing toners. In embodiments, crystalline copolymers, which are polyesters, may be synthesized from lactones, cyclic anhydrides, cyclic carbonates, and combinations thereof. These crystalline copolymers, in turn, may be utilized in the synthesis of toner particles.
专利号:US-2024308991-A1 优先权日:2021-01-15 标 题:Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material 发明人:SHIAO TZE CHIEH; MIGNANI SERGE; MOFFETT SERGE; VISHWAKARMA RAM 权利人:KORANEX CAPITAL 摘要:Carbohydrate of Formula (A)where R1 is H and n an integer from 1 to 5, is synthesized by reacting, under heating, compound (A0)with HO—(CH2)n—CHâ•?CH2 in the presence of an acid capable of liberating a proton, and cooling the reaction mixture to obtain a cooled mixture comprising compound (A).Carbohydrate of Formula (AAPG)where R2 is a monovalent protecting group, PG is a divalent protecting group and n an integer from 1 to 5, is synthesized by reacting, in the presence of a metal-containing zeolite, compound of Formula (APG)with compound of Formula (A1)where X is —I, —Br, —Cl, —CN, —OTf (Triflate), —OMs (Mesylate), —OTs (Tosylate), methylsulfate, or trichloroacetimidate. Deprotection of compound (AAPG) forms compound (AA)Carbohydrates (A) and (AA) can be coupled with a thiolated linker to form glycoconjugate precursors, which in turn are conjugatable with a carrier material such as a protein, peptide or polypeptide.
1: Ruan Z, Tang HF, Zhu HB. [Determination in the air of workplace dimethyl succinate and dimethyl glutarate and dimethyl adipate by gas chromatography]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 Dec 20;34(12):941-944. doi: 10.3760/cma.j.issn.1001-9391.2016.12.017. Chinese. doi: 10.1007/s10886-016-0685-z. Epub 2016 Mar 23. doi: 10.1128/AEM.00469-13. Epub 2013 Apr 26. 4: Wang Y, Cannon FS, Salama M, Fonseca DA, Giese S. Characterization of pyrolysis products from a biodiesel phenolic urethane binder. Environ Sci Technol. 2009 Mar 1;43(5):1559-64. 10: Trela BA, Bogdanffy MS. Cytotoxicity of dibasic esters (DBE) metabolites in rat nasal explants. Toxicol Appl Pharmacol. 1991 Sep 1;110(2):259-67.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 31(Suppl 1):5-76, 2012