CAS: 10603-52-8; 1-Benzylpyrrolidine-3-Carbonitrile

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132945-78-9 476493-40-0 1187930-86-4

上下游产品

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine acrylonitrile sodium cyanide (3R)-1-benzyl-3-methanesulfonyloxy pyrrolidine 1-benzyl-3-carboethoxypyrrolidine C-(1-benzyl-pyrrolidin-3-yl)-methylamine 1-benzyl-3-(methylamino)pyrrolidine (1-benzyl-pyrrolidin-3-yl)-(4-fluoro-phenyl)-methanone

📜1-苄基-3-氨基吡咯烷置于diethylzinc,4,5-双二苯基膦-9,9-二甲基氧杂蒽,Nickel Dichloride,Zinc Dibromide体系中,用 乙醇,二甲基亚砜 用作溶剂,化学反应 16.5H,反应生成1-苄基-3-氰基吡咯烷
参考文献:镍催化的脱氨基氰化:腈和烷基胺的一碳同系化
标题:镍催化的脱氨基氰化:腈和烷基胺的一碳同系化
摘要:已开发出一种镍催化的 Katritzky 吡啶鎓盐的脱氨基氰化反应.当它与由伯胺形成吡啶鎓盐结合时,该方法能够将烷基胺转化为烷基腈.使用毒性较小的氰化物试剂 Zn(Cn) 2,并且可以耐受多种官能团和杂环.除了多功能腈基的许多其他潜在转化之外,该方法还可以通过还原腈产物实现烷基胺的单碳同系化.
Doi:10.1021/acs.Orglett.1C01959

专利信息

专利号:US-7737159-B2
优先权日:2004-01-21
标 题:Antibacterial compounds
发明人：ANDERSON DAVID D; BEUTEL BRUCE A; COOPER CURT S; GU YU-GUI; HINMAN MIRA M; KALVIN DOUGLAS M; KEYES ROBERT F; SEARLE XENIA B; WAGNER ROLF
权利人:ABBOTT LAB
摘要:Bacterial protein synthesis-inhibiting compounds having formula (I) n n n n n n n n n n and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.

专利号:US-8946422-B2
优先权日:2005-07-27
标题:8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
发明人：BRADBURY BARTON JAMES; WILES JASON ALLAN; WANG QIUPING; HASHIMOTO AKHIRO; LUCIEN EDLAINE; PAIS GODWIN CLARENCE GILROY; DESHPANDE MILIND; PUCCI MICHEAL JOHN; KIM HA YOUNG
权利人:BRADBURY BARTON JAMES; WILES JASON ALLAN; WANG QIUPING; HASHIMOTO AKHIRO; LUCIEN EDLAINE; PAIS GODWIN CLARENCE GILROY; DESHPANDE MILIND; PUCCI MICHEAL JOHN; KIM HA YOUNG; ACHILLION PHARMACEUTICALS INC
摘要:The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R6, R7, and R9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.