CAS: 93176-00-2; 3-Hydroxy-6-Methoxy-2-Phenyl-4H-Chromen-4-One
该化合物是一种氟氯素衍生物,其特征是三,六位置的氢氧基和甲氧基功能组,该化合物显示出显著的生物活动,包括抗氧化剂和潜在的抗炎特性,其原因是它有能力对自由基进行蒸馏和调节细胞信号路径;其结构特征与较简单的氟氯素相比,增强了稳定性和生物利用率,使其成为制药和营养学研究的宝贵中间体.该化合物的纯度和定义明确的分子结构确保实验应用中的可复制性,特别是在侧重于氧化应力和代谢条例的研究中.该化合物通常用于生物化学实验和作为分析化学的参考标准.
- 英文名称3-Hydroxy-6-Methoxy-2-Phenyl-4H-Chromen-4-One
- 中文名称3-羟基-6-甲氧基黄酮
- IUPAC名称3-hydroxy-6-methoxy-2-phenyl-4H-chromen-4-one
- 其它别名3-Hydroxy-6-Methoxy-2-Phenyl-4H-Chromen-4-One; 3-Hydroxy-6-Methoxyflavanone; Ogurjsopvfcioo-Uhfffaoysa-N; 3-Hydroxy-
- CAS编号93176-00-2
- MFCD编号:MFCD00017639
- 分子式:C16H12O4分子量:268.27
- 产品CID: 1970256
- 产品分类生物化工 → 提取物
物理性质
MSDS等安全信息
上下游产品
6-methoxyflavanone 6-methoxy-3-nitro-2-phenyl-2H-chromene 2'-hydroxy-5'-methoxychalcone 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one hydroquinone benzoic acid 3-(allyloxy)-6-methoxy-2-phenyl-4H-chromen-4-one 3-Hydroxy-6-methoxyflavone 3-glucuronide合成工艺路线路线简述
- 705-15-7 + 100-52-7 = 93176-00-2
反应条件:1.1 Reagents: Oxygen Catalysts: Pyrrolidine Solvents: Water; 24 H,50 °C; 50 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4,Cooled
标题:Synthesis Of Flavonols Via Pyrrolidine Catalysis: Origins Of The Selectivity For Flavonol Versus Aurone
作者:Xiong,Wei; Wang,Xiaohong; Shen,Xianyan; Hu,Cuifang; Wang,Xin; Et Al
参考文献:Journal Of Organic Chemistry 日期:2020 卷标:85(20) 页码:13160-13176]
705-15-7 + 100-52-7 = 93176-00-2
反应条件:1.1 Catalysts: Lithium Hydroxide Solvents: Water; 1 H,Rt1.2 Reagents: Hydrogen Peroxide Solvents: Water; 5 H,Rt
标题:Convenient "On-Water" One-Pot,Synthesis Of Flavonols Catalyzed By Lioh.H2O- And H2O2-Mediated Oxidation
作者:Kumar,Sumit; Ambatwar,Ramesh; Gupta,Vaibhav; Khatik,Gopal L.
参考文献:Research On Chemical Intermediates 日期:2023 卷标:49(3) 页码:901-915]
3033-90-7 = 93176-00-2
反应条件:1.1 Reagents: Hydrogen Peroxide Solvents: Ethanol
标题:Exploring The Anti-Breast Cancer Potential Of Flavonoid Analogs
作者:Thakor,Vanrajsinh; Poddar,Mayur; Dey,Sumit; Manjula,S. N.; Madhunapantula,Subbarao V.; Et Al
参考文献:Rsc Advances 日期:2016 卷标:6(82) 页码:79166-79179]
= 93176-00-2 [标题:Reaction Conditions
标题:A Novel Synthesis Of 6-Methoxy And 7-Methoxy Flavonols
作者:Rao,Takkellapati Sudhakar; Deshpande,Shubhada; Mathur,Hari Har; Trivedi,Girish Kumar
参考文献:Heterocycles 日期:1984 卷标:22(9) 页码:1943-6]
59-88-1 + 861313-87-3 = 93176-00-2
反应条件:1.1 Reagents: Diethylamine Solvents: Acetonitrile; 25 °C
标题:Method For The Synthesis Of C-Arylation Product Of Benzopyranones And 1,4-Pyranones
参考文献:India]
861313-87-3 = 93176-00-2
反应条件:1.1 Reagents: Diethylamine Solvents: Acetonitrile; 4 H,Rt
标题:Hydroxyl Directed C-Arylation: Synthesis Of 3-Hydroxyflavones And 2-Phenyl-3-Hydroxy Pyran-4-Ones Under Transition-Metal Free Conditions
作者:Paul,Sayantan; Bhattacharya,Asish K.
参考文献:Organic & Biomolecular Chemistry 日期:2018 卷标:16(3) 页码:444-451]
3034-04-6 = 93176-00-2
反应条件:1.1 Reagents: Lithium Hydroxide,Hydrogen Peroxide Solvents: Methanol,Tetrahydrofuran,Water; 10 H,0 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
标题:Discovery Of A Prenylated Flavonol Derivative As A Pin1 Inhibitor To Suppress Hepatocellular Carcinoma By Modulating Microrna Biogenesis
作者:Zheng,Yuanyuan; Pu,Wenchen; Li,Jiao; Shen,Xianyan; Zhou,Qiang; Et Al
参考文献:Chemistry - An Asian Journal 日期:2019 卷标:14(1) 页码:130-134]
705-15-7 + 100-52-7 = 93176-00-2
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 12 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized1.3 Reagents: Sodium Hydroxide,Hydrogen Peroxide Solvents: Ethanol,Water; 0 °C; 12 H,Rt1.4 Reagents: Hydrochloric Acid Solvents: Water; Neutralized
标题:Ruthenium(Ii)-Catalyzed Synthesis Of Spirobenzofuranones By A Decarbonylative Annulation Reaction
作者:Kaishap,Partha P.; Duarah,Gauri; Sarma,Bipul; Chetia,Dipak; Gogoi,Sanjib
参考文献:Angewandte Chemie 日期:2018 卷标:57(2) 页码:456-460
📜6-甲氧基黄烷酮置于双氧水,Lithium Hydroxide体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,化学反应 10.0H,反应生成 3-羟基-6-甲氧基黄酮
参考文献:通过调节microrna的生物合成作为pin1抑制剂抑制肝细胞癌的prenylated黄酮醇衍生物的发现.
标题:通过调节microrna的生物合成作为pin1抑制剂抑制肝细胞癌的prenylated黄酮醇衍生物的发现.
摘要:肽脯氨酰顺-反异构酶中pin1在人类癌症的发展至关重要的作用.最近,我们披露了pin1调节mirna的生物发生,Mirna在hcc中异常表达并促进hcc进展,表明pin1在hcc治疗中的治疗作用.在此,7-(苄氧基)-3,5-二羟基-2-(4-甲氧基苯基)-8-(3-甲基丁-2-烯-1-基)-4H-铬-4--1(af-39)被鉴定为新型的pin1抑制剂.生化试验表明,Af-39有效抑制中pin1活性,其ic 50的1.008μ值米,并且还显示中肽基脯氨酰异构酶对中pin1高选择性.此外,Af‐39以剂量和时间依赖性方式显着抑制hcc细胞的细胞增殖.从机制上讲,Af-39调节xpo5的亚细胞分布并增加hcc细胞中mirna的生物发生.这项工作为hcc治疗提供了有希望的先导化合物,突出了基于mirna的疗法对人类癌症的治疗潜力.
DOI:10.1002/asia.201801461
海关参考信息
- 2905110000-甲醇
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
