CAS: 9007-92-5; Glucagon Hydrochloride(Human)

该化合物是胰腺细胞的甲型细胞产生的一种激素,主要与葡萄糖新陈代谢有关;它在保持血液甘蔗水平方面发挥着关键作用,特别是在节食或低能状态期间,通过促进肝脏中的血清分解和葡萄素产生;在结构上,Glucagon由29种氨酸组成,形成单一链状聚醚;在水中溶解,分子重量约为3,500 Da.Glucagon通过Glucagon受体,G蛋白混合受体进行的行为,导致各种代谢效应.在临床环境中,Glucagon被用作治疗严重缺血病的药物,并用作某些医学成像程序的一种诊断辅助剂.其稳定性受诸如pH和温度等因素的影响,并且通常以浸泡形式储存,以保持其功效.CAS编号9007-92-5提到对glucagon进行具体分类,在化学数据库和管制框架中协助其识别.

英文名称Glucagon Hydrochloride(Human)
中文名称胰高血糖素
IUPAC名称(3S)-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
其它别名His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
CAS编号9007-92-5
MFCD编号:MFCD03428060
EINECS号:232-708-2
分子式:C153H226ClN43O49S分子量:3519.21
产品CID: 1932220
产品分类生物化工 → 多肽

相似结构搜索
InChIKey: MASNOZXLGMXCHN-ZLPAWPGGSA-N
1S/C153H225N43O49S.ClH/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-1
计算化学: 氢键受体数55.0氢键供体数55.0可旋转键数115.0

物理性质

熔点-15 °C
沸点230 °C at 760 mm Hg
PSA:1564.04
LogP:0.3911
溶解性Methanol (Very Slightly, Heated, Sonicated), Water
敏感性pH2.3～3.0的水溶液4°C时可保存3个月
外观形态粉末
储存条件2-8°C

MSDS等安全信息

警示词Danger
危险描述H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
防范说明P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P317, P321, P333+P317, P342+P316, P362+P364, P403, and P501
UN编号NONH for all modes of transport
安全声明22-24/25
WGK Germany3

合成工艺路线路线简述

71989-16-7 + 71989-28-1 + 73731-37-0 + 139262-23-0 + 91000-69-0 + 29022-11-5 + 35661-60-0 + 35737-15-6 + 144120-53-6 + 92954-90-0 + 68858-20-8 + 71989-20-3 + 35661-39-3 + 35661-40-6 + 73724-45-5 + 116611-64-4 = 9007-92-5
反应条件:1.1 Reagents: Oxygen; Rt1.2 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.3 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.4 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.5 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.6 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.7 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.8 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.9 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.10 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.11 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.12 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.13 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.14 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.15 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.16 Reagents: Diisopropylcarbodiimide,1-Hydroxybenzotriazole Solvents: Dimethylformamide; 2 - 4 H,Rt1.17 Reagents: Trifluoroacetic Acid,Thioanisole,Phenol,1,2-Ethanedithiol,Water; 2.5 H,Rt
标题:α/sulfono-γ-Aapeptide Hybrid Analogs Of Glucagon With Enhanced Stability And Prolonged In Vivo Activity
作者:Sang,Peng; Zeng,Hongxiang; Lee,Candy; Shi,Yan; Wang,Minghui; Et Al
参考文献:Journal Of Medicinal Chemistry (2021 日期:Journal Of Medicinal Chemistry (2021),64(18),13893-13901 | Language: English,Database: Caplus And Medline 卷标:13893-13901 | Language: English 页码:Database: Caplus And Medline]

71989-16-7 + 71989-28-1 + 73731-37-0 + 105047-45-8 + 119062-05-4 + 91000-69-0 + 29022-11-5 + 35661-60-0 + 35737-15-6 + 92954-90-0 + 68858-20-8 + 71989-20-3 + 35661-39-3 + 35661-40-6 + 73724-45-5 + 116611-64-4 = 9007-92-5 [标题:Reaction Conditions
标题:Glucagon And A Glucagon-Glp-1 Dual-Agonist Increases Cardiac Performance With Different Metabolic Effects In Insulin-Resistant Hearts
作者:Axelsen,L. N.; Keung,W.; Pedersen,H. D.; Meier,E.; Riber,D.; Et Al
参考文献:British Journal Of Pharmacology (2012 日期:British Journal Of Pharmacology (2012),165(8),2736-2748 | Language: English,Database: Caplus And Medline 卷标:2736-2748 | Language: English 页码:Database: Caplus And Medline