CAS: 84680-75-1; (2S,3R,4S,5R)-5-Hydroxy-2-(((2Ar,3R,4S,5As,5Bs,7S,7Ar,9S,11Ar,12As)-4-Hydroxy-3-((2R,5S)-5-(2-Hydroxypropan-2-yl)-2-Methyltetrahydrofuran-2-yl)-2A,5A,8,8-Tetramethyl-7-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetra

该化合物是天然化合物,主要来自传统医学常用植物Astragalus membranaceus的根,属于沙邦氏菌类,具有类固醇或丙烯酸酯,以其潜在的药理特性而著称,包括免疫分子,抗氧化剂和抗炎效应.该化合物的特点是能够加强免疫功能和促进细胞健康,使其对草药和现代药理都感兴趣.通常研究其在防止氧化性压力方面的作用及其在各种健康条件下的潜在好处,包括心血管疾病和糖尿病.Astragaladoloside I在水和有机溶剂中是可溶的,有助于提取和使用各种配方.其安全性特征一般被认为是有利的,但还需要进一步研究,以充分了解其行动和治疗潜力的机制.

英文名称(2S,3R,4S,5R)-5-Hydroxy-2-(((2Ar,3R,4S,5As,5Bs,7S,7Ar,9S,11Ar,12As)-4-Hydroxy-3-((2R,5S)-5-(2-Hydroxypropan-2-yl)-2-Methyltetrahydrofuran-2-yl)-2A,5A,8,8-Tetramethyl-7-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)Tetra
中文名称黄芪皂苷I
IUPAC名称(2S,3R,4S,5R)-5-hydroxy-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-hydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-7-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-9-yl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate
其它别名20,24-Epoxycycloartane-3,16,25-Triol-6-O-Beta-D-Glucopyranoside; Astragaloside I; Astrasieversianin Iv; Cyclosieversioside B; Cyclosiversioside B; Astragaloside I(Sh); Astragaloside I (Astrasieversianin Iv; Astragaloside L, , From Astragalus Membranaceus Bunge
CAS编号84680-75-1
MFCD编号:MFCD30478908
FDA UNII编号:24CT26I88H
分子式:C45H72O16分子量:869.05
产品CID: 1836280
产品分类生物化工 → 中草药成分

相似结构搜索
InChIKey: GBPDDYORNLOZID-YVEOHGMNSA-N
InChI=1S/C45H72O16/c1-21(47)56-33-24(50)19-55-38(34(33)57-22(2)48)60-28-11-13-45-20-44(45)15-14-41(7)35(43(9)12-10-29(61-43)40(5,6)54)23(49)17-42(41,8)27(44)16-25(36(45)3
计算化学: 氢键受体数16.0氢键供体数7.0可旋转键数11.0

物理性质

熔点246-250°C
沸点910.6±65.0 °C at 760 mmHg
闪点265.5±27.8 °C
密度1.4±0.1 g/cm3
pKa:12.87±0.70(预测)
PSA:240.36
LogP:0.94
折射率1.603
蒸汽压0.0±0.6 mmHg at 25°C
溶解性Methanol (Slightly), Pyridine (Slightly)
外观形态白色至类白色固体
储存条件2-8°C(避光保存)
产品应用该化合物用作内容确定,识别和药理研究.

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P280-P301+P312-P302+P352-
UN编号NONH for all modes of transport
危险品标志Xi
安全声明H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
WGK Germany3

上下游产品

CAS号84605-18-5 环黄芪醇 | CAS号83207-58-3 黄芪甲苷A(黄芪甲苷 IV)

合成工艺路线路线简述

84687-43-4 = 84680-75-1 + 86764-11-6 + 84676-88-0 + 84676-89-1
反应条件:1.1 Solvents: Water; 48 H,Rt
标题:Microbial Transformation Of Astragalosides To Astragaloside Iv By Absidia Corymbifera As2
作者:Ye,Li; Et Al
参考文献:Process Biochemistry (Amsterdam 日期:2011 卷标:46(9) 页码:1724-1730

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合成参考文献

参考文献:10.1055/s-2006-957642
摘要:Caliş I, Yürüker A, Taşdemir D, Wright AD, Sticher O, Luo YD, Pezzuto JM. Cycloartane triterpene glycosides from the roots of Astragalus melanophrurius. Planta Med. 1997 Apr;63(2):183–6. doi: 10.1055/s-2006-957642.
参考文献:10.1248/cpb.31.698
摘要:KITAGAWA I, WANG H, SAITO M, TAKAGI A, YOSHIKAWA M. Saponin and sapogenol. XXXV. Chemical constituents of astragali radix, the root of Astragalus membranaceus Bunge. (2). Astragalosides I,II and IV, acetylastragaloside I and isoastragalosides I and II. Chem. Pharm. Bull. 1983;31(2):698–708. doi: 10.1248/cpb.31.698.