CAS: 82386-89-8; 2-Chloro-5-(Trifluoromethyl)Benzaldehyde

上下游产品

CAS号64372-62-9 2-氯-5-(三氟甲基)苯甲醇 | CAS号22902-87-0 2-Chloro-5-trif... | CAS号75-17-2 甲醛肟(10%的水溶液,约2.... | CAS号121-50-6 3-氨基-4-氯三氟甲苯 | CAS号22902-87-0 2-Chloro-5-trif... | CAS号64372-62-9 2-氯-5-(三氟甲基)苯甲醇 | CAS号1693-28-3 2-三氟甲基噻吨酮

1-氯-2-(氯甲基)-4-(三氟甲基)苯置于potassium Dichromate,苄基三乙基氯化铵,水,Potassium Acetate体系中,用 二氯甲烷 作为反应溶剂,化学反应 12.0H,反应生成 2-氯-5-三氟甲基苯甲醛
参考文献:Tricyclic Psychotropic Agents Containing Two Chalcogen Atoms In The Central Ring: Derivatives Of 11H-Dibenz[b,F]-1,4-Oxathiepin
标题:Tricyclic Psychotropic Agents Containing Two Chalcogen Atoms In The Central Ring: Derivatives Of 11H-Dibenz[b,F]-1,4-Oxathiepin
摘要:2-溴苄溴和其类似物xvii和xxv与2-羟基硫代苯酚的反应产生了11H-二苯[b,F]-1,4-噁硫杂环戊烷(Ia)及其2-氯(Ib)和2-三氟甲基衍生物(Ic).从ia和ib衍生的锂化合物与二氧化碳和二甲基氨基烷氯化物的处理得到化合物iia,Va和viab;侧链的改变导致胺类化合物iva,Viia和viiia.通过用亚硫酰氯或n-氯琥珀酰亚胺氯化物氯化化合物ibc,然后用1-甲基-4-哌啶基氯化镁处理,得到11-(1-甲基-4-哌啶基)衍生物xbc.化合物ib经氧化转化为磺酮xx,经过与氢化钠和叔-氨基烷基氯化物处理得到基本磺酮xxi和xxii.核未取代的带有脂肪侧链的胺类化合物(Iva和viia)具有强烈的抗利血平活性,是潜在的抗抑郁药物,而骨架2位有取代基的11-(1-甲基-4-哌啶基)衍生物(Xbc)是潜在的神经阻滞剂;特别是三氟甲基衍生物xc具有出色的猫病和抗阿波莫啡效果.
DOI:10.1135/cccc19820967

专利信息

专利号:WO-2013091696-A1
优先权日:2011-12-21
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:WO-2012085133-A1
优先权日:2010-12-23
标 题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof

专利号:US-2014135368-A1
优先权日:2010-12-23
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof

专利号:US-5734067-A
优先权日:1994-09-28
标题 :Anti-oxidative tricyclic, condensed heterocyclic compound
发明人：JINNO SHUJI; KOGURE YASUYO; ONUKI HIROYUKI; OKITA TAKAAKI
权利人:NIPPON SUISAN KAISHA LTD
摘要:Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condensed heterocyclic compound represented by the following formula: ##STR1## (wherein X--Y represents CH 2 --Câ•?O, CH 2 --CH 2 or CHâ•?CH; Z represents O, S, or Sâ•?O; R 1 to R 8 represent independently those selected from the group consisting of hydrogen atom, a hydroxyl group, a halogen group, a lower alkyl group, a lower alkoxyl group, a lower alkyl ketone group and CF 3 ; and at least two of R 1 to R 4 are hydroxyl groups); and the salts thereof are provided. The compound has an anti-oxidative activity at the same degree as or higher than the activity of α-tocopherol, so the compound is promising as a therapeutic drug for a variety of diseases, such as cancer, arteriosclerosis, or liver diseases, in which it is believed that biological lipid peroxides may b involved.