CAS: 6945-92-2; Ethyl 2-Hydrazinylacetate Hydrochloride

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CAS号14150-64-2 2-肼基乙酸 | CAS号179474-55-6 2-(2-methanehyd... | CAS号6301-02-6 1-氨基海因 | CAS号30979-39-6 2-(3-甲基-5-氧代-4,... | CAS号623-73-4 重氮乙酸乙酯 | CAS号14150-64-2 2-肼基乙酸 | CAS号63981-22-6 3-(5-nitrofurfu...

N-Boc-肼乙酸乙酯置于盐酸体系中,用 乙醇,水 作为反应溶剂,以98.4%的收率获得产物肼基乙酸乙酯盐酸盐
参考文献:一种肼基乙酸乙酯盐酸盐的制备方法
标题:一种肼基乙酸乙酯盐酸盐的制备方法
摘要:本发明公开了一种肼基乙酸乙酯盐酸盐的制备方法,属于有机合成技术领域.本发明的技术方案要点为:利用氯乙酸乙酯或溴乙酸乙酯为起始物料,经与肼基甲酸叔丁酯反应上叔丁基保护基,脱保护,成盐酸盐,制得肼基乙酸乙酯盐酸盐.本发明具有反应条件温和,收率高,纯度高,成本低,经济环保和适用于产业化等优点,是一种具有工业生产价值的合成方法.

专利信息

专利号:US-8178474-B1
优先权日:1999-04-21
标题 :Functionalised solid support for alpha-oxoaldehyde synthesis
发明人：MELNYK OLEG; FRUCHART JEAN-SEBASTIEN; BOUREL LINE; GRAS-MASSE HELENE
权利人:MELNYK OLEG; FRUCHART JEAN-SEBASTIEN; BOUREL LINE; GRAS-MASSE HELENE; PASTEUR INSTITUT; CENTRE NAT RECH SCIENT
摘要:The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one α-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one α-oxoaldehyde function and to the α-oxoaldehyde peptides obtained using this process.

专利号:FR-2792631-A1
优先权日:1999-04-21
标题:Solid supports for the synthesis of compounds having an alpha-oxo-aldehyde group and peptides, made by solid phase synthesis using such supports

专利号:EP-2436673-A1
优先权日:2010-09-30
标 题:Curcumin derivatives with improved physicochemical properties and nanoliposomes surface-decorated with the derivatives with very high affinity for amyloid-beta1-42 peptide
发明人：ANTIMISIARI SOPHIA; MOURTAS SPIRIDON; NIARAKI ANNA; ZONA CRISTIANO; MASSERINI MASSIMO; NICOTRA FRANCESCO; LA FERLA BARBARA
权利人:NIARAKI ANNA; UNIV PATRAS; UNIV MILANO BICOCCA; ANTIMISIARI SOFIA; MOURTAS SPIRIDON
摘要:Amyloid β (Aβ) aggregates are considered as possible targets for therapy and/or diagnosis of Alzheimer disease (AD). It has been previously shown that curcumin targets Aβ plaques and interferes with their formation, suggesting a potential role for prevention or treatment of AD. In the present invention, curcumin-derivatives with improved physicochemical properties were synthesized and a 'click chemistry' as well as a conventional liposome preparation method, were used to generate nanoliposomes decorated with the curcumin derivatives. These derivatives were designed to maintain the planar structure required for interaction with Aβ, as directly confirmed by Surface Plasmon Resonance experiments. Surface Plasmon Resonance experiments, measuring the binding of flowing liposomes to immobilized Aβ1-42, indicated that the liposomes exposing curcumin derivatives have extremely high affinity for Aβ1-42 fibrils (1-5 nM), likely because of the occurrence of multivalent interactions. The present invention describes the synthesis of the curcumin derivatives and the preparation and characterization of new nanoliposomes with a very high affinity for Aβ1-42 fibrils, to be exploited as vectors for the targeted delivery of new diagnostic and therapeutic molecules for AD.

专利号:US-11312722-B2
优先权日:2019-05-08
标 题:Hsp90 inhibitors and uses thereof
发明人：BROWN LAUREN ELAINE; HUANG DAVID S; COWEN LEAH E; WHITESELL LUKE; MARCYK PAUL
权利人:UNIV BOSTON; GOVERNING COUNCIL UNIV TORONTO
摘要:Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.

专利号:CN-119954778-A
优先权日:2025-01-27
标题 :Synthesis method of lenacipam sodium and series of intermediate compounds thereof

专利号:CN-110845356-B
优先权日:2019-11-19
标 题 :Synthesis method of hydrazino ethyl acetate hydrochloride