CAS: 65473-13-4; N-Methyl-1-(Naphthalen-1-yl)Methanamine Hydrochloride

上下游产品

N-methyl-1-naphthalenecarboxamideH-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide1-methyl-4-phenyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide4-(4-chloro-phenyl)-1-methyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide4-phenyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide p-tolyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide4-p-tolyl-1H-pyrrole-3-carboxylic acid methyl-naphthalen-1-ylmethyl-amide

N-甲基萘-1-甲酰胺置于红铝体系中,用 苯 作为反应溶剂,以86%的收率获得产物n-甲基-1-萘甲胺盐酸盐
参考文献:合成具有布替萘芬结构元件构象固定的潜在角鲨烯环氧化酶抑制剂
标题:合成具有布替萘芬结构元件构象固定的潜在角鲨烯环氧化酶抑制剂
摘要:报道了萘甲胺 6B-H 的合成,其中将空间要求增加的取代基引入 α 位置以进行构象固定.由于萘基烷酮 3 与胺 9 和 10 的还原胺化现在可以在非常有限的范围内使用,因此首先以各种方式合成 α-取代萘甲胺 2 和 4 作为合适的中间体,然后才合成所需的 N 取代模式目标化合物通过合适的-主要是还原-烷基化方法建立.
DOI:10.1002/ardp.19933260607

专利信息

专利号:US-6506701-B1
优先权日:1996-05-03
标题:Rapid purification by polymer supported quench
发明人：BOLTON GARY L; BOOTH RICHARD J; CRESWELL MARK W; HODGES JOHN C; WARMUS JOSEPH S; WILSON MICHAEL W
权利人:WARNER LAMBERT CO
摘要:Novel polymer-supported quenching reagents of Formula I,whereinP is a polymer of low chemical reactivity which is soluble or insoluble;Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; andL is one or more chemically robust linkers that join P and Q;are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

专利号:WO-0039055-A1
优先权日:1998-12-23
标 题:Rapid purification by polyaromatic quench reagents
发明人：DA SILVA MARIANNE; DOWNING DENNIS MICHAEL; WARMUS JOSEPH SCOTT; ZHANG LU-YAN
权利人:WARNER LAMBERT CO; DA SILVA MARIANNE; DOWNING DENNIS MICHAEL; WARMUS JOSEPH SCOTT; ZHANG LU YAN
摘要:Novel polyaromatic hydrocarbon quenching reagents of Formula (I), wherein: P is a polyaromatic hydrocarbon of low chemical reactivity which is soluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers or dendritic linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

专利号:CN-112552182-A
优先权日:2020-11-20
标 题 :A new synthesis process of naftifine pharmaceutical intermediate N-methyl-1-naphthylmethylamine

专利号:CN-112552182-B
优先权日:2020-11-20
标题 :A new synthesis process of naftifine pharmaceutical intermediate N-methyl-1-naphthylmethylamine