CAS: 638-29-9; Valeryl Chloride

上下游产品

CAS号109-52-4 正戊酸 | CAS号6920-22-5 1,2-己二醇 | CAS号98-88-4 苯甲酰氯 | CAS号107-27-7 氯化乙基汞 | CAS号814-68-6 丙烯酰氯 | CAS号75-44-5 光气 | CAS号10415-86-8 para-cresyl valerate | CAS号100536-61-6 N-[2-(Diethylam... | CAS号102502-67-0 1,2-dichloro°Ct... | CAS号33228-44-3 4-戊基苯胺 | CAS号33083-83-9 5-十一酮 | CAS号39815-78-6 3-氧代庚酸甲酯 | CAS号584-93-0 2-溴戊酸 | CAS号4312-99-6 1-辛烯-3-酮 | CAS号54410-90-1 4-戊基环己醇(顺反混合物)

正戊酸置于氯化亚砜体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 戊酰氯
参考文献:1-戊酰基-N-{[2'-(1H-四唑-5-基)联苯-4-基]甲基}-吡咯烷-2-甲酰胺:结构变化的研究
标题:1-戊酰基-N-{[2'-(1H-四唑-5-基)联苯-4-基]甲基}-吡咯烷-2-甲酰胺:结构变化的研究
摘要:我们最近报道了一系列 1-酰基-N-(联苯-4-基甲基)吡咯烷-2-甲酰胺作为 At1 受体配体.该系列中最有效的化合物,1-戊酰基-N-{[2'-(1H-四唑-5-基)联苯-4-基]甲基}-吡咯烷-2-甲酰胺,对受体表现出有趣的亲和力. 为了研究结构变化对亲和力的影响,已经进行了属于该系列的其他化合物的合成.在稳定表达人 At1 受体的 Cho-Hat1 细胞上对新合成的化合物进行的生物测试证实了我们之前的假设,即在这个系列中,酰基链的长度,酰胺基团的取代和酸性物质的性质其中一个对受体相互作用至关重要,分别是戊酸链,二级酰胺功能和四唑部分,
DOI:10.1002/ardp.201000296

专利信息

专利号:US-11168050-B2
优先权日:2014-03-27
标 题 :Efficient synthesis of amines and amides from alcohols and aldehydes by using cascade catalysis
发明人：CÓRDOVA ARMANDO; BERGLUND PER; ANDERSON MATTIAS; AFEWERKI SAMSON
权利人:XP CHEMISTRIES AB
摘要:The present invention relates generally to an eco-friendly methodology for the conversion of alcohols and aldehydes to amines and amides using an integrated enzyme cascade system with metal- and organocatalysis. More specifically, the present invention relates to synthesis of capsaicinoids starting from vanillin alcohol and using a combination of an enzyme cascade system and catalysts. Furthermore, the method also relates to synthesis of capsaicinoids derivatives starting from vanillin alcohol derivatives and using a combination of an enzyme cascade system and catalysts.

专利号:US-6849743-B2
优先权日:1997-08-15
标 题 :Synthesis of clasto-lactacystin β-lactone and analogs thereof
发明人：SOUCY FRANCOIS; FLAMONDON LOUIS; BEHNKE MARK; ROUSH WILLIAM
权利人:MILLENNIUM PHARM INC
摘要:The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel stereospecific synthesis of an oxazoline intermediate and a unique stereoselective addition of a formyl amide to the oxazoline. Also described are novel clasto-lactacystin-β-lactones, and analogs thereof and their use as proteasome inhibitors.

专利号:US-3682895-A
优先权日:1970-07-17
标题 :Synthesis of 3-hydroxy-5-bufa-20,22-dienolide
发明人：PETTIT GEORGE R; FESSIER DYRAL C; PAUIL KENNETH D
权利人:GEORGE R PETTIT; DYRAL C FESSIER; KENNETH D PAUIL
摘要:THERE IS PROVIDED A NOVEL METHOD OF SYNTHEESIZING 5ABUFADIENOLIDES, WHICH ARE USEFUL INTERMEDIATES IN THE TOTAL SYNTHESIS OF BUFALIN, A CARDIAC ACTIVE COMPOUND. EPIANDROSTERONE ACETATE IS CONVERTED INTO 3B - ACETOXYL-5APREGNANE-21-AL WHICH UNDERGOES CHAIN EXTENSION TO METHYL 3B-ACETOXYL-20-FORMYL-21-NOR-5A-CHOLANATE WHICH IS RING CLOSED TO FORM THE 3B - ACETOXY-5-A-BUF-20(21)-ENOLIDE WHICH IS DEHYDROGENATED TO THE CORRESPONDING BUFADIENOLIDE.

专利号:WO-0146695-A1
优先权日:1999-12-08
标 题:Novel supports for solid phase synthesis
发明人：ANTONENKO VALERY V; THIELE JOCHEN; ATUEGBU ANDY E
权利人:GLAXO GROUP LTD; ANTONENKO VALERY V; THIELE JOCHEN; ATUEGBU ANDY E
摘要:Novel solid supports and methods for their use in the synthesis of chemical compounds by the sequential addition of chemical building blocks are provided. The solid support comprises a polymer having reactive groups (for example, poly(styrene-co-vinylbenzyl chloride)) grafted to a chemically inert bulk material (such as a Teflon® membrane).

专利号:US-4803287-A
优先权日:1986-04-16
标题 :Certain photochromic fulgide compounds and method for their synthesis
发明人：HIBINO JUNICHI; ANDO EIJI
权利人:AGENCY IND SCIENCE TECHN
摘要:The invention provides a photochromic material characterized by an improvnt in balance of the substituents in the conventional furylfulgides and represented by the general formula: ##STR1## (wherein R represents an alkyl chain having 5 to 31 carbon atoms). According to this molecular structure, a mutually appropriate steric hindrance is induced between the isopropylidence group and the long-chain alkyl group to make the regio isomer unstable, thus preventing the regio isomer from being by-produced while also inhibiting any isomerization reaction from occuring in the synthesis of the fulgide. Further, a good balance of hydrophilic part and hydrophobic part is produced to facilitate formation of a Langmuir-Blodgett film.

专利号:US-2022064111-A1
优先权日:2019-01-17
标 题:Enantioselective synthesis of brivaracetam and intermediates thereof
发明人：ROY SARABINDU; GHOSH ANGSHUMAN; KUBEER RAMESH DHONDI; PRASAD MUTYALA V V VARA; PAUL GOPAL; GARAI ABHISHEK; CHAKRABORTY SOURAV; HALDAR ANIMESH; YADAW AJAY KUMAR; ROY SUBHO
权利人:CLININVENT RES PVT LTD
摘要:The present invention relates to an improved and economical process for enantioselective synthesis and purification of a novel key intermediate of Brivaracetam. Further, the present invention also relates to a process for the preparation of a chirally pure Brivaracetam of formula I utilizing the said intermediate.