专利号:US-12350400-B1 优先权日:2024-07-03 标题 :Biodegradable nanocomposite surgical screw containing bone nanoparticles 发明人:HOSSAIN A B M SHARIF; RUDAYNI HASSAN AHMED; ALEISSA MOHAMMAD SAAD; ZAHRANY MOHAMMED MUSA; ALHUDHAIBI ABDULRAHMAN; RAHMAN FAZLINY ABDUL 权利人:IMAM MOHAMMAD IBN SAUD ISLAMIC UNIV 摘要:A nanocomposite derived from organic sources, including waste date seeds, pomegranate peels and camel knee bone. The nanocomposites can be used for the synthesis of surgical implants, are biodegradable, and do not require surgery for their removal. The nanocomposites contain nanoparticles of date seeds, pomegranate peels, camel knee bone, polymers, organic substances, and organic dyes. A method for the preparation of the nanocomposites includes molding the nanocomposites into organic bone screws, bone plates, and dental prosthetics.
专利号:US-2013131146-A1 优先权日:2010-04-30 标题:Compositions and Methods for Treating Pulmonary Conditions 发明人:VIJ NEERAJ; BODAS MANISH 权利人:VIJ NEERAJ; BODAS MANISH; UNIV JOHNS HOPKINS 摘要:The present invention relates to the role of cystic fibrosis transmembrane conductance regulator (CFTR) in pulmonary conditions. In one embodiment, a method for assessing the severity of lung damage from a pulmonary condition in a subject comprises the steps of (a) measuring the level and/or functional activity of membrane/lipid-raft cystic fibrosis transmembrane conductance regulator (CFTR)in a sample from the subject; (b) measuring the level of ceramide or its species in a sample from the subject; and (c) comparing the membrane/lipid- raft CFTR level and/or functional activity and ceramide level to a control sample, wherein a difference in membrane/lipid-raft CFTR level and/or functional activity and ceramide level is indicative of the severity of lung damage. The method can further comprise treating the subject based on the severity of lung damage. In particular embodiments, the treatment comprises administering a CFTR agonist and/or an agent that inhibits the synthesis of ccramide or its species.
专利号:US-9289365-B2 优先权日:2011-10-24 标 题 :Compositions and methods for stimulating collagen synthesis in the skin 发明人:HWANG CHENG; LYGA JOHN; HU HONG 权利人:HWANG CHENG; LYGA JOHN; HU HONG; AVON PROD INC 摘要:Cosmetic compositions comprising substituted carbamoyl heterocyclic analogs and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The substituted carbamoyl heterocyclic analogs are believed to have modulatory activity against one or more biochemical pathways implicated in skin aging.
专利号:CN-103864747-B 优先权日:2014-03-28 标题 :Total Synthesis of Mangostin
专利号:US-2004146539-A1 优先权日:2003-01-24 标 题:Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits 发明人:GUPTA SHYAM K 摘要:I have discovered cosmetic or topical pharmaceutical compositions for external body part or organ slimming, firming, cellulite reduction, fat-reduction, and obesity control benefits that are in synergistic combination with benefits for the treatment of skin aging, skin wrinkles reduction, skin exfoliating, treatment of acne, treatment of rosacea, age-spots reduction, skin surface whitening, skin surface brightening striae distensae (stretch marks) reduction, treatment of pimples, treatment of skin infections and lesions, spider veins reduction, blood microcirculation (venous insufficiency) improvement, UVA/UVB protection of skin, and skin redness reduction. These compositions thus provide multiple combinations of skin and external body part or organ enhancement benefits that can be selective and specific for external body parts and organs such as face, chin, cheeks, arms, “love handlesâ€? in abdomen area, eye lids and eye zone, neck, breasts, thighs, and hips. These compositions include a body beneficial composition selected from certain nutraceutical, cosmetic, and pharmaceutical ingredients, a composition to promote collagen and elastin synthesis in the skin, and a cosmetically or pharmaceutically acceptable delivery ystem.
专利号:CN-115612114-A 优先权日:2021-07-14 标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis
1: Lee J, Kang JS, Choi BY, Keum YS. Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin. Biomol Ther (Seoul). 2016 Nov 1;24(6):604-609. doi: 10.4062/biomolther.2016.028. doi: 10.1038/srep32743. 4: Guo M, Wang X, Lu X, Wang H, Brodelius PE. α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF. PLoS One. 2016 Sep 1;11(9):e0161566. doi: 10.1371/journal.pone.0161566. 5: Phitaktim S, Chomnawang M, Sirichaiwetchakoon K, Dunkhunthod B, Hobbs G, Eumkeb G. Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana L. and oxacillin against an oxacillin-resistant Staphylococcus saprophyticus. BMC Microbiol. 2016 Aug 26;16(1):195. doi: 10.1186/s12866-016-0814-4.
合成参考文献
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