CAS: 59528-27-7; (4-Iodophenyl)Methanamine Hydrochloride

该化合物是一种卤代芳香衍生物,广泛用作有机合成和制药研究的多用途构件;该化合物的特点是反应性主要矿物质组,便于其在恐吓,还原作用和其他组合反应中使用;碘代用加强了其在交叉反应中的效用,如铃木或松木木树结合,使苯基胺元体能够引入复杂的分子框架;盐盐形式确保改善稳定性和处理;该化合物由于其平衡的再反应性和结构灵活性,在药用化学中对于发展生物活性分子(包括酶抑制剂和受体等)具有特别宝贵的价值.

英文名称(4-Iodophenyl)Methanamine Hydrochloride
中文名称对碘苄胺盐酸盐
IUPAC名称(4-iodophenyl)methanamine hydrochloride
其它别名4-Iodobenzylamine Hcl; Benzenemethanamine, 4-Iodo-, Hydrochloride; 4-Iodobenzylamine, Hcl; (4-Iodophenyl)Methanaminehydrochloride; Gbjmurrfwzrehe-Uhfffaoysa-N; 4-Iodobenzylamine Hydrochloride, 95%; 1-(4-Iodophenyl)Methanamine--Hydrogen
CAS编号59528-27-7
MFCD编号:MFCD04039324
EINECS号:676-636-3
分子式:C7H9ClIN
分子量:269.51
产品CID: 1571986
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;
InChIKey: GBJMURRFWZREHE-UHFFFAOYSA-N
InChI=1S/C7H8IN.ClH/c8-7-3-1-6(5-9)2-4-7;/h1-4H,5,9H2;1H…
计算化学: 氢键受体数1.0氢键供体数1可旋转键数1

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明S22-S24/25
危险类别码R36/37/38
WGK Germany3

欧盟法规

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合成工艺路线路线简述

4-碘苄醇置于盐酸,一水合肼,三苯基膦,偶氮二甲酸二乙酯体系中,用四氢呋喃,甲醇,甲苯作为反应溶剂,化学反应生成 4-碘苄胺盐酸盐
参考文献:Design,Synthesis,And Evaluation Of Isoindolinone-Hydroxamic Acid Derivatives As Histone Deacetylase (Hdac) Inhibitors
标题:Design,Synthesis,And Evaluation Of Isoindolinone-Hydroxamic Acid Derivatives As Histone Deacetylase (Hdac) Inhibitors
摘要:We Designed And Synthesized Hydroxamic Acid Derivatives Bearing A 4-(3-Pyridyl)Phenyl Group As A Cap Structure,And Found That They Exhibit Potent Historic Deacetylase (Hdac) Inhibitory Activity. A Representative Compound,17A,Showed More Potent Growth-Inhibitory Activity Against Pancreatic Cancer Cells And Greater Upregulation Of P21(Waf1/cip1) Expression Than The Clinically Used Hdac Inhibitor Suberoylanilide Hydroxamic Acid (Zolinza (Tm)). (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2007.06.038