专利号:WO-9915510-A1 优先权日:1997-09-24 标 题:Protecting and linking groups for organic synthesis 发明人:TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY 权利人:ALCHEMIA PTY LTD; TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY 摘要:This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups which are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis. In its most general aspect, the invention provides a cyclic compound of general formula (I).
专利号:US-6765089-B1 优先权日:1997-09-24 标 题 :Protecting and linking groups for organic synthesis on solid supports 发明人:TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY 权利人:ALCHEMIA PTY LTD 摘要:This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups that are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis.
专利号:WO-9509170-A1 优先权日:1993-09-28 标 题:Chemical synthesis of rhodamine derivatives 发明人:CORRIE JOHN EDGAR THOMAS; CRAIK JAMES STANLEY 权利人:MEDICAL RES COUNCIL; CORRIE JOHN EDGAR THOMAS; CRAIK JAMES STANLEY 摘要:A method for preparing rhodamine derivatives of formulae (a) or (b) or a mixture of such compounds, where X is bromo, chloro- or iodoacetamido, maleimido, or amino. These compounds are the 5 and 6 (or 5' and 6') isomers of the amine, haloacetamide and maleimide derivatives of tetramethylrhodamine. The method enables for the first time the production of isomerically pure compounds on a relatively large scale. The products are fluorescent and are useful for the labelling of proteins.
专利号:US-4757149-A 优先权日:1986-12-31 标 题:Synthesis of bis(N-substituted phthalimide)ethers 发明人:MARESCA LOUIS M 权利人:GEN ELECTRIC 摘要:Bis(N-substituted phthalimide)ethers are synthesized in a one-step process by heating a compound of the formula (I): ##STR1## with a catalytic amount of an alkali or alkaline earth metal carbonate in a polar aprotic solvent under ether-forming conditions, and recovering the bis(N-substituted phthalimide)ether from the reaction mixture. R 1 is hydrogen; a monovalent organic radical selected from a lower alkyl group having from 1 to about 10 carbon atoms, preferably from 1 to about 5 carbon atoms; or an aromatic hydrocarbon radical, or halogenated derivative thereof, having from about 6 to about 20 carbon atoms. X is a leaving group.
专利号:US-2011263540-A1 优先权日:2008-07-25 标题 :Small-molecule inhibitors of protein synthesis inactivating toxins 发明人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.
专利号:US-8362234-B2 优先权日:2006-03-24 标题 :Solid support reagents for synthesis 发明人:HATALA PAUL J; KURZ MARKUS 权利人:ARCHEMIX LLC; HATALA PAUL J; KURZ MARKUS 摘要:The present invention relates to a compound according to the formula: n nwherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Y, Z, n, s, and t are as defined herein. These compounds are useful for methods of solid phase synthesis.
[参考文献]: Vu H Nguyen, Et Al. Synthesis And Biological Characterisation Of 18F-Sig343 And 18F-Sig353, Novel And High Selectivity σ2 Radiotracers, For Tumour Imaging Properties. Ejnmmi Res. 2013 Dec 11;3(1):80.
合成参考文献
摘要:National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina. 摘要:McKeown, N. B., Science of Synthesis, (2004) 17, 1269.