CAS: 535935-84-3; 6,7-Dihydro-5H-Cyclopenta[b]Pyridin-5-Amine

该化合物是一种环环环有机化合物,其特点是双环结构,包括环球环的环状环,该化合物具有一种矿物质功能组,有助于其潜在的反应和生物活动;环和矿群中氮原子的存在可影响其溶性,极度和与生物目标的相互作用;一般而言,这种性质的化合物可能具有药理特性,使其对医药化学感兴趣;分子结构允许采用各种替代模式,从而进一步改变其化学行为和生物活动;此外,该化合物在药物开发或作为化学中间体的稳定性,再活性和潜在应用可能受到其特定的电子和化学特性的影响.

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1187930-17-1 2765452-27-3 2739982-66-0

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CAS号1071727-80-4 6,7-dihydro-[1]...

合成工艺路线路线简述

    📜6,7-Dihydro-[1]Pyrindin-5-One O-Methyl-Oxime置于钯体系中,用 三氟乙酸 作为反应溶剂,化学反应 14.0H,反应生成 6,7-二氢-5H-环戊并[b]吡啶-5-胺
    参考文献:Substituted Fluoroethyl Ureas As Alpha 2 Adrenergic Agents
    标题:Substituted Fluoroethyl Ureas As Alpha 2 Adrenergic Agents
    摘要:本文披露了治疗化合物,以及与之相关的方法,组合物和药物.

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    专利信息


    专利号:US-7094909-B2
    优先权日:2001-06-11
    标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
    发明人:KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
    权利人:AGOURON PHARMA
    摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.

    专利号:US-9428490-B2
    优先权日:2011-07-29
    标 题 :Nuclear transport modulators and uses thereof
    发明人:SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD
    权利人:SANDANAYAKA VINCENT P; SHACHAM SHARON; KAUFFMAN MICHAEL; SHECHTER SHARON; MCCAULEY DILARA; LANDESMAN YOSEF; SENAPEDIS WILLIAM; SAINT-MARTIN JEAN-RICHARD; KARYOPHARM THERAPEUTICS INC
    摘要:The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.

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