CAS: 4299-70-1; Tryptophan Methyl Ester

上下游产品

CAS号6159-33-7 (S)-(-)-tryptop... | CAS号14464-20-1 (2S)-2-(benzyla... | CAS号171489-59-1 (1R,3R)-1-(1,3-... | CAS号171596-27-3 12-表-他达拉非 | CAS号171596-36-4 去甲基他达那非 | CAS号171596-28-4 6-表-他达拉非 | CAS号171596-29-5 他达那非 | CAS号487-89-8 3-吲哚甲醛 | CAS号616-34-2 甘胺酸甲酯 | CAS号73-22-3 L-色氨酸 | CAS号67-56-1 甲醇

L-色氨酸置于三甲基氯硅烷,碳酸氢钠体系中,化学反应 4.0H,反应生成 L-色氨酸甲酯
参考文献:由 L-色氨酸合成 2,4,5-三取代-1H-吡咯-3-醇型化合物的无溶剂三组分:反应机理和 3H-吡咯-3-One↔1H-吡咯的 Dft-B3Lyp 计算-3-Ol 互变异构平衡
标题:由 L-色氨酸合成 2,4,5-三取代-1H-吡咯-3-醇型化合物的无溶剂三组分:反应机理和 3H-吡咯-3-One↔1H-吡咯的 Dft-B3Lyp 计算-3-Ol 互变异构平衡
摘要:在本文中,我们描述了从 L-色氨酸无溶剂合成 2,4,5-三取代-1H-吡咯-3-醇类化合物的三组分合成.合成方法的第一步涉及以极好的收率 (93-98%) 酯化 L-色氨酸.在无溶剂条件下加热烷基 2-氨基酯,1,3-二羰基化合物和氢氧化钾 (0.1 当量) 的等摩尔混合物.以中等至非常好的产率 (45%-81%) 获得标题化合物.使用"becke,3-Parameter,Lee-Yang-Parr"相关泛函 (Dft-B3Lyp) 计算进行密度泛函理论以了解合成化合物的分子稳定性和 3H-Pyrrol-3-One 型中间体的互变异构平衡到 1H-Pyrrol-3-Ol 型芳香环.
DOI:10.3390/molecules25194402

专利信息

专利号:US-9353112-B2
优先权日:2012-03-07
标 题 :Synthesis of polycyclic alkaloids
发明人：GOFF DANE; PAYAN DONALD G; BRASELMANN SYLVIA
权利人:RIGEL PHARMACEUTICALS INC
摘要:Disclosed embodiments concern polycyclic alkaloid compounds and methods for their use and synthesis. Particular embodiments concern polycyclic alkaloids having a fused, six-membered ring, while other embodiments concern polycyclic alkaloids having a fused, five-membered ring. Methods for making the polycyclic alkaloids are disclosed, as well as methods for their use as prophylactics or treatments for certain diseases. Also disclosed are pharmaceutical compositions comprising the polycyclic alkaloids and their use.

专利号:US-2023220381-A1
优先权日:2020-06-30
标 题 :Dna-encoded functionalized aptamers
发明人：SLEIMAN HANADI; LACROIX DE VIMEUR DE ROCHAME DONATIEN PHILIPPE MARIE; MCKEAGUE MAUREEN; HIRKA SERHII; SALIBA DANIEL; ANDERSON SHAUN IAN
权利人:THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIV
摘要:It is provided the synthesis of an aptamer-like encoded oligomer (ALEnOmer), method of producing same and method of preparing a library of ALEnOmes. More particularly, the method of preparing ALEnOmer comprises coupling at least one phosphoramidite monomer with an orthogonal protecting group, and the ALEnOmer produces comprises a DNA coding strand covalently attached to an oligomer through a branching unit, wherein the oligomer has a degree of polymerization at least 5 and is an aptamer.

专利号:WO-0053545-A1
优先权日:1999-03-10
标 题 :Process for the synthesis of dihydropyridones
发明人：BUNIN BARRY A; TUSHUP STEVEN P
权利人:AXYS PHARM INC; BUNIN BARRY A; TUSHUP STEVEN P
摘要:This invention relates to a process of synthesizing dihydropyridone compounds of Formula (I). The process of the present invention can also be used to synthesize a library of dihydropyridone compounds represented by Formula (I).

专利号:US-8703951-B2
优先权日:2011-07-15
标 题 :Synthesis of 4H-benzo[D]pyrrolo[1,2-A]thiazoles and indolizino[6,7-b]indole derivatives and their use as antitumor therapeutic agents
发明人：SU TSANN-LONG; CHOU TING-CHAO; LEE TE-CHANG
权利人:SU TSANN-LONG; CHOU TING-CHAO; LEE TE-CHANG; ACADEMIA SINICA
摘要:The present invention provides a series of 2,3-bis(hydroxymethyl)-4H-benzo[d]pyrrolo-[1,2-a]thiazoles and 1,2-bis(hydroxymethyl)indolizino[6,7-b]indole derivatives and their bis(alkylcarbamates) derivatives. These derivatives were designed as bi-functional DNA cross-linking agents. The in vitro cytotoxicity study of these compounds revealed that they exhibit significant anti-proliferative activity in inhibiting human lymphoblastic leukemia and various solid tumor cell growth. The compounds also exhibit therapeutic efficacy against human breast carcinoma and lung cancer in xenograft model. The compounds generally possess potent antitumor activity to kill various human solid tumors and have high potential for clinical applications.

专利号:US-5780603-A
优先权日:1996-11-15
标题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SYNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccaride derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccaride derviatives.

专利号:US-5965719-A
优先权日:1996-11-15
标 题:Combinatorial synthesis of carbohydrate libraries
发明人：HINDSGAUL OLE
权利人:SUNSORB BIOTECH INC
摘要:Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.