CAS: 42872-74-2; 3-Bromo-4-Methylbenzonitrile

上下游产品

CAS号104-85-8 对甲苯腈 | CAS号183723-09-3 3-溴-4-甲基苯甲酰胺 | CAS号7697-26-9 3-溴-4-甲基苯甲酸 | CAS号7745-91-7 3-溴-4-甲基苯胺 | CAS号3816-66-8 3-羟基-4-甲基苯腈 | CAS号3556-60-3 3-甲氧基-4-甲基苯腈 | CAS号1943-88-0 4-甲基-异酞腈 | CAS号7697-26-9 3-溴-4-甲基苯甲酸 | CAS号183723-09-3 3-溴-4-甲基苯甲酰胺 | CAS号863868-32-0 4-甲基-3-(4,4,5,5... | CAS号867333-43-5 2-甲基-5-氰基苯硼酸 | CAS号89892-39-7 3-溴-4-(溴甲基)苯腈 | CAS号90110-98-8 3-溴-4-(羟基甲基)苯甲腈 | CAS号90484-53-0 3-溴-4-甲酰基苯甲酸甲酯

对甲苯腈置于br2-Hydantoin体系中,用 三氟乙酸 作为反应溶剂,以87%的收率获得产物3-溴-4-甲基苯甲腈
参考文献:Carboxylate-Directed Kumada Coupling Of An Acetaldehyde Synthon With 2-Bromobenzoates Used Towards The Synthesis Of Isochromanes
标题:Carboxylate-Directed Kumada Coupling Of An Acetaldehyde Synthon With 2-Bromobenzoates Used Towards The Synthesis Of Isochromanes
摘要:这封信描述了溴苯甲酸衍生物与乙醛烯醇合成物(1,3-二氧杂环戊基)溴化镁的熊谷偶联反应.锂羧酸盐在偶联反应中表现出最高的反应活性,而添加t-Buoli则提供了最佳的选择性.在这项工作中,我们观测到了钠羧酸盐功能的强烈导向效应,这在区分电子类似的二芳基溴化物时是很有用的.
DOI:10.1055/s-2007-985572

专利信息

专利号:US-9550000-B2
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：ROBINSON SIMON P; YU MING
权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

专利号:US-11299484-B2
优先权日:2018-10-10
标 题 :Inhibiting fatty acid synthase (FASN)
发明人：MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.

专利号:EP-1345954-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives

专利号:EP-1345954-A2
优先权日:2000-12-21
标 题:Methods utilizing aryl thioimines in synthesis of erythromycin derivatives

专利号:WO-0250093-A2
优先权日:2000-12-21
标题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives

专利号:US-2022339303-A1
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents