CAS: 367-23-7; 1,2,4-Trifluorobenzene

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2,4-二氯氟苯置于sodium Phosphite,硫酸,氢气,硝酸,Copper(II) Oxide体系中,用 环丁砜,甲醇,水 用作溶剂,180.0 °C,800.01 Kpa 条件下,反应 4.5H,反应生成1,2,4-三氟苯
参考文献:一种1,2,4-三氟苯的合成方法
标题:一种1,2,4-三氟苯的合成方法
摘要:本发明提供了一种1,2,4‑三氟苯的合成方法,属于农药,医药,液晶材料中间体制备领域.它解决了现有合成1,2,4‑三氟苯反应条件苛刻等问题,一种1,2,4‑三氟苯的合成方法,其特征在于,包括如下步骤:以2,4‑二氯氟苯为原料,以硝酸为硝化试剂,在硫酸存在的条件下硝化生成2,4‑二氯‑5‑氟硝基苯;将2,4‑二氯‑5‑氟硝基苯溶解于有机溶剂中,加入氟化钾和第一催化剂,在第一催化剂的催化下氟化得到2,4,5‑三氟硝基苯;将2,4,5‑三氟硝基苯溶于溶剂中,和氢气在第二催化剂的催化下氢化还原得到2,4,5‑三氟苯胺;2,4,5‑三氟苯胺先与硫酸反应,成盐后再与亚硝基硫酸发生重氮化反应,然后在铜盐的催化下与次亚磷酸钠发生脱氨基还原反应,最后经水汽蒸馏得到1,2,4‑三氟苯.本发明具有反应条件温和等优点.

专利信息

专利号:US-7276637-B2
优先权日:2002-08-02
标题:Synthesis of cyclohexanone derivatives
发明人：BRANDS KAREL MARIE JOSEPH; DAVIES ANTONY JOHN; OAKLEY PAUL JOSEPH; SCOTT JEREMY PETER; SHAW DUNCAN EDWARD; TEALL MARTIN RICHARD
权利人:MERCK & CO INC
摘要:A novel process for preparing cyclohexanone derivatives of formula (I) n nis described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-4565896-A
优先权日:1984-10-22
标 题 :Process for low pressure synthesis of ethylene glycol from synthesis gas
发明人：KNIFTON JOHN F; DURANLEAU ROGER G
权利人:TEXACO INC
摘要:This invention relates to the manufacture of ethylene glcyol and more particularly to a low pressure process for making ethylene glycol comprising reacting synthesis gas, i.e. a mixture of carbon monoxide and hydrogen, plus formaldehyde in the presence of a homogeneous liquid catalyst containing an effective amount of cobalt-containing compound and a silicon or germanium-containing promoter and a solvent at a temperature of at least 50 DEG C. and a pressure of at least 500 psi wherein said ethylene glycol product separates as a separate liquid phase from the solvent.

专利号:US-4568780-A
优先权日:1984-10-22
标 题 :Process for low pressure synthesis of ethylene glycol from synthesis gas plus 1,3-dioxolane
发明人：KNIFTON JOHN F
权利人:TEXACO INC
摘要:This invention relates to the manufacture of ethylene glycol and more particularly to a low pressure process for making ethylene glycol comprising reacting synthesis gas, i.e. a mixture of carbon monoxide and hydrogen, plus 1,3-dioxolane in the presence of a homogenous liquid catalyst containing an effective amount of cobalt-containing compound and a silane or germane-containing promoter dispersed in a hydrocarbon solvent at a temperature of at least 50 DEG C. and a pressure of at least 500 psi, where the particular solvents used allow the desired product to be separated from the reaction mixture by phase separation.

专利号:US-10913747-B2
优先权日:2017-07-04
标题 :Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
发明人：DE LUCCHI OTTORINO; PADOVAN PIERLUIGI; BRASOLA ELENA
权利人:FIS FABBRICA ITALIANA SINTETICI SPA; F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.

专利号:US-7468459-B2
优先权日:2003-03-19
标题:Process for the preparation of chiral beta amino acid derivatives by asymmetric hydrogenation
发明人：XIAO YI; ARMSTRONG III JOSEPH D; KRSKA SHANE W; NJOLITO EUGENIA; RIVERA NELO R; SUN YONGKUI; ROSNER THORSTEN
权利人:MERCK & CO INC
摘要:The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.