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CAS号4815-36-5 2-氨基-4-苯基噻吩-3-羧酸乙酯 | CAS号77287-34-4 甲亚胺酸 | CAS号18593-67-4 2-methyl-5-phen... | CAS号182198-35-2 4-氯-5-苯基噻吩并[2,3-d]嘧啶

📜2-(1-苯基亚乙基)丙二腈置于碳酸氢钠,Sulfur体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 6.0H,反应生成 5-苯基-3H-噻吩[2,3-D]-嘧啶-4-酮
参考文献:一类多取代喹诺酮类化合物及其制备方法和用途
标题:一类多取代喹诺酮类化合物及其制备方法和用途
摘要:本发明提供了一类多取代喹诺酮类化合物及其制备方法和用途,具体地,本发明提供了一种如下式ⅰ所示的多取代喹诺酮化合物,其光学异构体,及药学上可接受的盐或溶剂合物,其中各基团的定义如说明书中所述.本发明的喹诺酮化合物具有非常好的c-Met抑制活性,可以用于c-Met活性或表达量相关疾病的治疗.

专利信息

专利号:US-2004138238-A1
优先权日:2002-08-08
标题 :Substituted aminopyrimidine compounds as neurokinin antagonists
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; KESAVAN VENKITASAMY; SHARADENDU ANURAG; MOHANTY PRADYUMNA; CHEN DONGLI; CHERUKU SRINIVASA RAO; HEIFETZ ALEXANDER; KALID ORI; MARANTZ YAEL; NUDELMAN RAPHAEL; SBACHAM SHARON; BAR-HAIM SHAY
摘要:The invention discloses tachykinin receptor antagonists. The tachykinin family of receptors comprising the neurokinins substance P (SP), neurokinin A, and neurokinin B and related neuropeptides that are widely distributed in the peripheral and central nervous system. The invention discloses novel aminopyrimidine derivatives, synthesis and uses thereof for the treatment of diseases mediated directly or indirectly by the tachykinin receptors. These diseases include central nervous system disorders such as anxiety, pain, depression, emesis, in particular cancer chemotherapy induced emesis, respiratory and inflammatory bowel disease and other gastric disorders, asthma, schizophrenia, ophthalmic diseases such as glaucoma, ocular hypotension, neural injury, stroke, cardiac disorders, psoriasis, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.