CAS: 3459-18-5; 4-Nitrophenyl 2-Acetamido-2-Deoxy-Beta-D-Glucopyranoside

相似化合物

14948-96-0 23646-68-6 13089-27-5

上下游产品

CAS号13089-27-5 4-硝基苯基-2-乙酰氨基-3... | CAS号3068-34-6 2-乙酰氨基-3,4,6-三-... | CAS号100-02-7 对硝基苯酚 | CAS号824-78-2 4-硝基苯酚钠 | CAS号7512-17-6 N-乙酰-D-氨基葡萄糖 | CAS号3006-60-8 2-(乙酰氨基)-2-脱氧-B... | CAS号7284-16-4 4-硝基苯基-Β-D-N,N'... | CAS号57467-16-0 p-nitrophenyl 2... | CAS号57467-13-7 4-硝基苯基 2-乙酰氨基-2... | CAS号19234-58-3 4-Nitrophenyl2-... | CAS号7284-16-4 4-硝基苯基-Β-D-N,N'... | CAS号4350-20-3 (E)-5-cyclohexy... | CAS号7512-17-6 N-乙酰-D-氨基葡萄糖 | CAS号100-02-7 对硝基苯酚 | CAS号132498-72-7 4-硝基苯基2-乙酰氨基-2-... | CAS号13089-27-5 4-硝基苯基-2-乙酰氨基-3...

📜D-Glcnac置于palladium Diacetate,2-氯-1,3-二甲基氯化咪唑啉,三乙胺体系中,用 水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 1.0H,反应生成 4-硝基苯基-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷
参考文献:由水中的还原糖直接合成对硝基苯基糖苷.
标题:由水中的还原糖直接合成对硝基苯基糖苷.
摘要:可以使用2-氯-1,3-二甲基咪唑啉鎓氯化物(dmc),对硝基苯酚和合适的碱在水溶液中将还原糖直接转化为相应的对硝基苯基(p Np)糖苷.对于在2位具有羟基或乙酰氨基的糖,该反应是立体选择性的,产生1,2-反式p Np糖苷.碱的明智选择允许扩展至二糖和寡糖底物,包括从天然来源分离的复杂的n-聚糖低聚糖,而无需任何保护基团的操作
DOI:10.1021/acs.Orglett.0C00728

专利信息

专利号:EP-0725144-A1
优先权日:1995-02-06
标题 :Process for the preparation of glycosides using glycosidases from ciliates
发明人：KIY THOMAS DR; HOERSCH BRIGITTE DR; MARQUARDT RUEDIGER DR
权利人:HOECHST AG
摘要:The invention relates to a process for the production of glycosides by enzymatic glycosylation by means of α- and β-glycosidases from holotrich ciliates and in particular from Hymenostomatida.n n n Glycosidases from holotrich ciliates are very well suited for the enzymatic synthesis of alkyl glycosides, glycopeptides, di- or oligosaccharides. Preferred glycosyldoren are nitrophenylglycosides, glycosyl fluorides or disaccharides, preferred acceptors are short-chain alcohols, polyhydroxy compounds, in particular monosaccharides, or protected hydroxyamino acids or corresponding peptides.

专利号:US-2025011792-A1
优先权日:2021-12-01
标题:Irap inhibitors for use in the treatment of inflammatory diseases
发明人：HERMINE OLIVIER; WEIMERSHAUS MIRJANA; TROVATI MACIEL THIAGO; VAN ENDERT PETER; DUSSIOT MICHAEL; RIGNAULT-BRICARD RACHEL; CARVALHO CAROLINE
权利人:INST NAT SANTE RECH MED; ASSIST PUBLIQUE HOPITAUX PARIS APHP; FOND IMAGINE; UNIV PARIS CITE; CENTRE NAT RECH SCIENT
摘要:Upon activation, mast cells rapidly release preformed inflammatory mediators from large cytoplasmic granules via regulated exocytosis. This acute degranulation is followed by a late activation phase involving synthesis and secretion of cytokines, growth factors and other inflammatory molecules via the constitutive pathway that remains ill-defined. Here the inventors describe a role for an insulin-responsive vesicle-like endosomal compartment, marked by insulin-regulated aminopeptidase (IRAP), in the secretion of TNF-α and IL-6 in mast cells and macrophages. IRAP-deficient mice are protected from TNF-dependent kidney injury and inflammatory arthritis. In the absence of IRAP, TNF fails to be efficiently exported from the Golgi. Chemical targeting of IRAP+ endosomes reduced pro-inflammatory cytokine secretion thereby highlighting this compartment as a promising target for the therapeutic control of inflammation. Thus the present invention relates to the use of IRAP inhibitors for the treatment of inflammatory diseases

专利号:US-5852005-A
优先权日:1994-07-27
标 题:Tetracyclic triterpenes
发明人：HIESTAND PETER; NAEF RETO; NAEGELI HANS-ULRICH; OBERER LUKAS; REVESZ LASZLO; ROTH HANS-JOERG
权利人:NOVARTIS AG
摘要:The present invention relates to 17 α-dammara compounds having immunosuppressant and antiinflammatory activity and which are useful as pharmaceuticals, particularly for use as immunosuppressant and antiinflammatory agents. Specific 17 α-dammara compounds are included per se, for example the compound of formula IC, i.e. 17 α-23-(E)-dammara-20, 23-dien-3β, 25-diol, which may be obtained from the flour of the shoots of the Palmyrah palm, Borassus flabellifer L. In addition, processes for the synthesis of this and other dammara compounds and intermediates thereof are described.

专利号:US-4918009-A
优先权日:1985-12-11
标 题:Method of controlling the regioselectivity of glycosidic bonds
发明人：NILSSON KURT G I
权利人:SVENSKA SOCKERFABRIKS AB
摘要:A method of controlling the regioselectivity of the glycosidic bond between glycosyl donor and glycosyl acceptor in the enzymatic production of an oligosaccharide compound which either consists of or is a fragment or an analog of the cabohydrate part in a glycoconjugate, by reverse hydrolysis or transglycosidation reactions, is described. The synthesis is carried out in that a donor substance which is a mono- or oligosaccharide or a glycoside thereof, is caused to react, in the presence of a glycosidase, with an acceptor substance which is an O-, N-, C- or S-glycoside consisting of a monosaccharide, oligosaccharide or a saccharide analog and at least one aglycon which is O-, N-, C- or S-glycosidically bonded in 1-position, the alpha or beta -configuration being selected on the glycoside bond between the glycosyl group and the aglycon in the acceptor substance, and the oligosaccharide compound being separated from the reaction mixture.

专利号:US-5433947-A
优先权日:1992-12-15
标 题 :Antifungal synergistic combination of enzyme fungicide and non-enzymatic fungicide and use thereof
发明人：HARMAN GARY E; LORITO MATTEO; PIETRO ANTONIO D; HAYES CHRISTOPHER K
权利人:CORNELL RES FOUNDATION INC
摘要:Antifungal composition comprising synergistic combination of fungal cell wall degrading enzyme selected from the , group consisting of chitinolytic enzymes, glucanolytic enzymes and cellulases and non-enzymatic fungicides selected from the group consisting of sterol synthesis inhibiting fungicides (e.g., flusilazole and miconazole) and thiol group inactivating fungicides which are not specific to fungal cell membranes (e.g., captan) are applied in an antifungal effective amount to fungus to be inhibited or to a locus to be protected from said fungus.

专利号:US-6090944-A
优先权日:1998-08-13
标 题:Alkanoic acid derivatives as αv integrin receptor antagonists
发明人：HUTCHINSON JOHN H
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3, αvβ5 and/or αvβ6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, and tumor growth and metastasis.