专利号:US-2005112158-A1 优先权日:2003-11-17 标 题 :Method for synthesis of silylated ascorbic acid derivatives 发明人:TERRY W L JR; LEGROW GARY E; LITTAU CHERYL 权利人:CLARIANT INTERNATINONAL LTD 摘要:A compound of Formula (I), as defined in the specification, and a method for its synthesis. The method includes providing an inert environment, minimizing exposure of the reaction environment to visible light and reacting ascorbic acid with solvent and a compound of the Formula (II), as defined in the specification. The method of the present invention produces increased yields and a compound having increased stability and the same or greater bioactivity than ascorbic acid. The compound formed by the method of the present invention is capable for use in anhydrous cosmetic, dermatological and pharmaceutical compositions as an active agent for combating aging of the skin and improving its aesthetic appearance.
专利号:US-7541458-B2 优先权日:2005-06-10 标题:β-lactam synthesis 发明人:VU PHONG; HOLTON ROBERT A 权利人:UNIV FLORIDA STATE RES FOUND 摘要:The present invention is directed to a process for the preparation of β-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the β-lactam product in a “one potâ€? synthesis, this process is generally performed at a higher temperature than conventional processes.
专利号:JP-2005145971-A 优先权日:2003-11-17 标题:Method for the synthesis of silylated ascorbic acid derivatives
专利号:EP-1531156-A1 优先权日:2003-11-17 标题 :Method for synthesis of silylated ascorbic acid derivatives
专利号:MX-2007015593-A 优先权日:2005-06-10 标题:SYNTHESIS OF BETA-LACTAMA.
参考文献:10.1007/s10545-007-0767-8 摘要:Wittmann G, Karg E, Mühl A, Bodamer OA, Túri S. Comparison of tetrahydrofuran and ethyl acetate as extraction solvents for urinary organic acid analysis. J Inherit Metab Dis. 2008 Feb;31(1):73–80. doi: 10.1007/s10545-007-0767-8.