CAS: 329909-29-7; 3-Fluoro-4-Methylbenzenesulfonamide

该化合物是一种有机化合物,其特点是附在苯环上的磺酰胺功能组,该功能组又被氟原子和甲基组所取代;分子结构的特点是氟原子相对于磺酰胺组的元体位置具有氟原子,而甲基组则处于其独特的化学特性;该化合物一般是白色至非白色固体,在极地溶剂中具有溶解性,因为磺酰胺具有形成氢联结的能力,而全氟辛烷磺酸的功能组因形成氢联结而很常见;氟素的存在可以增强化合物的脂性并影响其生物活动,使其对药用化学具有兴趣;此外,据了解,磺酰胺的抗菌特性及其结构的改变会影响其药理学特征;应参考安全数据,以便处理和使用,如同任何化学物质一样,确保采取适当的防范措施.

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CAS号90260-13-2 3-氟-4-甲基苯磺酰氯

合成工艺路线路线简述

    📜3-氟-4-甲基苯磺酰氯 反应 4.0H,以100%的收率获得3-氟-4-甲基甲苯磺酰胺
    参考文献: Fluoro-Containing Compounds,Use And Preparation Thereof[fr] Composés Fluorés,Utilisation Et Préparation De Ceux-Ci
    标题: Fluoro-Containing Compounds,Use And Preparation Thereof[fr] Composés Fluorés,Utilisation Et Préparation De Ceux-Ci
    摘要:本发明的教导涉及一种含氟化合物,其组合物,使用该化合物或组合物治疗疾病的方法以及制备该化合物的方法.在一个特定的实例中,所述化合物选自公式4,4F,7,8,9,10,11或12,或其盐,或前述任何物质的溶剂化物.

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    专利信息


    专利号:US-7169955-B2
    优先权日:2000-02-04
    标 题 :Perfluoroisopropylbenzene derivative
    发明人:ONISHI MASANOBU; IKEDA KENICHI; SHIMAOKA TAKASHI; YOSHIDA MASANORI
    权利人:NIHON NOHYAKU CO LTD
    摘要:Perfluoroisopropylbenzene derivatives of the general formula (I) or salts thereof, useful as intermediates or raw materials in the synthesis of various industrial materials including agricultural chemicals, drugs and surfactants: n nwherein X 1 is H, halogen, formyl, optionally halogenated (C 1 –C 6 ) alkyl, (C 1 –C 6 ) alkylthio, or the like; X 2 is H, halogen, formyl, hydroxyl, (C 1 –C 6 ) alkyl, —C(â•?O)—R 1 (wherein R 1 is H, halogen, hydroxyl, (C 1 –C 6 ) alkyl, or NR 2 R 3 , with R 2 and R 3 being each H, C 1-6 alkyl, or the like), or the like; X 3 is H, halogen, hydroxyl, cyano, isocyanate, hydrazino, diazo, —C(â•?O)—R 1 , —SO 2 —R 4 (wherein R 4 is halogen, hydroxyl, (C 1 –C 6 ) alkyl, or NR 5 R 6 , with R 5 and R 6 being each H or (C 1 –C 6 ) alkyl), or the like; and X 4 is H, halogen, (C 1 –C 6 ) alkyl, or (C 1 –C 6 ) alkoxy, with publicly known compounds beingexcepted.

    专利号:WO-2024115549-A1
    优先权日:2022-11-30
    标题:Aryl- and heteroaryl-sulfonamide derivatives as ccr8 modulators
    发明人:AISSAOUI HAMED; CORMINBOEUF OLIVIER; DIETHELM STEFAN; REMEN LUBOS; RICHARD-BILDSTEIN SYLVIA
    权利人:IDORSIA PHARMACEUTICALS LTD
    摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR8 receptor modulators in medicine.

    专利号:CN-113582926-B
    优先权日:2021-09-09
    标题:Synthesis method of 4-fluoroisoquinoline-5-sulfonyl chloride or pharmaceutically acceptable salt thereof

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    合成参考文献


    参考文献:10.1007/978-3-662-04164-2_2
    摘要:Hiyama T, Yamamoto H. Reagents for Fluorination. 2000. In: Organofluorine Compounds. : Springer Berlin Heidelberg; 2000.
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