CAS: 30992-29-1; Boc-Aib-Oh

相似化合物

15030-72-5 62-57-7 94744-50-0

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号62-57-7 2-氨基异丁酸 | CAS号84758-55-4 2-((叔丁氧羰基)氨基)-2... | CAS号142842-93-1 di-tert-butyl d... | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号123-91-1 1,4-二氧六环 | CAS号84758-57-6 2-((叔丁氧基羰基)氨基)-... | CAS号1070-19-5 Carbonazidic ac... | CAS号84758-56-5 B°C-Aib-OEt | CAS号77-71-4 5,5-二甲基海因 | CAS号62-57-7 2-氨基异丁酸 | CAS号102520-97-8 N-B°C-2-氨基-2-甲基-1-丙醇 | CAS号109608-77-7 (1,1-二甲基-2-氧代乙基... | CAS号146000-39-7 2-((叔丁氧基羰基)(甲基)... | CAS号159634-94-3 N-[N-[(1,1-二甲基乙... | CAS号17704-74-4 2-氨基-2-甲基-丙酰胺盐酸盐 | CAS号73470-46-9 B°C-2-氨基异丁酸酰胺

ocn-Aib-Ome置于hydroxide体系中,化学反应生成 N-叔丁氧羰基-2-甲基丙氨酸
参考文献:在13 C-NMR-谱和新方法中合成ph值为2-甲基丙氨酸的肽
标题:在13 C-NMR-谱和新方法中合成ph值为2-甲基丙氨酸的肽
摘要:通过13 C-NMR研究了不常见的氨基酸2-甲基丙氨酸(α-氨基异丁酸,Aib).关于相邻基团和氨基酸,讨论了aib的氨基或羧基保护的衍生物和受保护的寡肽的化学位移.研究了aib,Aib-Ala,Ala-Aib,Aib-Ala-Aib和aib-Ala-Aib-Ala-Aib的13 C-NMR光谱的ph依赖性.使用这些示例,首次展示了一种新的有利方法,用于评估NMR滴定曲线,该方法使用了所谓的化学位移图(cs图).
DOI:10.1016/0040-4020(82)85164-8

专利信息

专利号:US-6867202-B1
优先权日:1997-06-25
标 题 :Treatment of insulin resistance
发明人：CARPINO PHILIP ALBERT; CHIU CHARLES KWOK-FUNG; PAN LYDIA CODETTA; LEFKER BRUCE ALLEN; TREADWAY JUDITH LEE; ZAWISTOSKI MICHAEL PAUL
权利人:PFIZER
摘要:This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, n n nwhere the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and th compounds of formula I. This invention is further directed to methods comprising administering to a human or other animal a combination of a functional somatostatin antagonist such as an alpha-2 adrenergic agonist and a compound of formula I.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2019031650-A1
优先权日:2016-01-29
标 题 :Dna alkylation and cross-linking agents as compounds and payloads for targeted therapies
发明人：HERZON SETH; HEALY ALAN; CRAWFORD JASON; VIZCAINO MARIA; NIKOLAYEVSKIY HERMAN
权利人:UNIV YALE
摘要:The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.

专利号:US-6359144-B1
优先权日:1997-02-04
标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-2006167268-A1
优先权日:2002-04-09
标 题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-10968192-B2
优先权日:2018-09-26
标题:Crystalline solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis
发明人：BEDNARZ MARK STEPHEN; Dai Kuangchu; ECKERT JEFFREY MANNING; LIM NGIAP-KIE; SIROIS LAUREN; WU WENXUE; ZHAO MATTHEW MANGZHU
权利人:LEXICON PHARMACEUTICALS INC
摘要:Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide, and salts, solvates and cocrystals thereof, are disclosed.