CAS: 2949-22-6; Ethyl Isocyanatoacetate

相似化合物

24066-82-8 13641-96-8 623-33-6

上下游产品

phosgene glycine ethyl ester hydr°Chloride GlyOEt*HCl trichloromethyl chloroformate5-(4-chloro-phenyl)-hydantoic acid ethyl ester ethyl N-(4-nitrophenylamin°Carbonyl)glycinate ethyl dibenzoylglycinate Z-Gly-Gly-OEt

异氰基乙酸乙酯置于二甲基亚砜,三氟乙酸酐体系中,用 二氯甲烷 用作溶剂,化学反应 0.17H,以95%的收率获得异氰酰乙酸乙酯
参考文献:三氟乙酸酐催化 Dmso 氧化异腈:一种快速,方便的异氰酸酯合成
标题:三氟乙酸酐催化 Dmso 氧化异腈:一种快速,方便的异氰酸酯合成
摘要:三氟乙酸酐催化亚砜平稳有效地将异腈氧化为异氰酸酯.使用 Dmso 作为氧化剂和 5 Mol.% Tfaa(二氯甲烷,-60 至 0 oc),该过程在几分钟内完成,形成唯一的副产物二甲硫醚.新形成的异氰酸酯可以直接使用或通过溶剂蒸发以高纯度分离.
Doi:10.1021/ol200695Y

专利信息

专利号:US-12410140-B2
优先权日:2020-06-19
标题:Method for synthesis of roxadustat and intermediate thereof, and intermediate thereof
发明人：ZHANG YONG; WANG GUO; YANG FEI; LIU FENGWEI; ZHOU CHUNDONG; ZHANG ZITONG
权利人:JUMPCAN SHANGHAI MEDICAL TECH CO LTD
摘要:Disclosed are a method for the synthesis of roxadustat and an intermediate thereof, and an intermediate thereof. In particular, disclosed is a method for the synthesis of compound M1, the method comprising the following steps: carrying out a reaction as shown below between compound SM and compound SM-A under the action of an oxidizing agent. The method of the present invention uses cheap and easily available raw materials, has short reaction steps, produces a high yield, has simple and convenient post-treatment procedures, and is suitable for industrial production.

专利号:WO-9502566-A1
优先权日:1993-07-16
标题 :Synthesis of combinatorial arrays of organic compounds through the use of multiple component combinatorial array syntheses
发明人：ARMSTRONG ROBERT W
权利人:UNIV CALIFORNIA; ARMSTRONG ROBERT W
摘要:The present invention relates to an array of compounds having a common core structure wherein the compounds of the array comprise the products of a multiple component combinatorial array synthesis having at least three components. The present invention also relates to the method of synthesizing that array. A further embodiment of the present invention relates to the use of solid phase synthesis to synthesize the combinatorial array of compounds. The present invention also relates to a method of creating a combinatorial array of compounds with a common core structure by identifying the desired core structure, identifying an MCCA reaction capable of generating that core structure, followed by preparing an array of compounds using the identified MCCA reaction according to the aforementioned method. The present invention also relates to a method for conducting in vitro assays of biological material using the combinatorial arrays of the present invention.

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:US-2007173517-A1
优先权日:2006-01-20
标 题:Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
发明人：WIRTH THOMAS; KROEBER JUTTA; NICOLA THOMAS; RAPP ARMIN; GUTHEIL DIETER; ORLICH SIMONE A; WANG XIAO-JUN; KRISHNAMURTHY DHILEEPKUMAR
权利人:WIRTH THOMAS; KROEBER JUTTA; NICOLA THOMAS; RAPP ARMIN; GUTHEIL DIETER; ORLICH SIMONE A; WANG XIAO-JUN; KRISHNAMURTHY DHILEEPKUMAR
摘要:Disclosed is an improved multi-step process for preparing a compound of Formula I: n n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

专利号:US-7470795-B2
优先权日:2004-07-27
标 题:Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
发明人：WANG XIAO-JUN; WIRTH THOMAS; NICOLA THOMAS; ZHANG LI; FRUTOS ROGELIO PEREZ; XU YIBO; KRISHNAMURTHY DHILEEPKUMAR; NUMMY LAURENCE JOHN; VARSOLONA RICHARD J; SENANAYAKE CHRIS HUGH; KROEBER JUTTA; REEVES DIANA
权利人:BOEHRINGER INGELHEIM PHARMA; BOEHRINGER INGELHEIM INT
摘要:Disclosed is a multi-step process for preparing a compound of Formula I: n nwherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.