CAS: 25999-20-6; Lasalocid A Sodium Salt
该化合物是一种聚醚离子体抗生素,主要用作牲畜饲料添加剂,以促进生长和提高饲料效率;其特点是能够将钠和钾等单价电离子,穿过生物膜,改变离子平衡,影响细胞过程;该化合物通常被描述为白粉或白粉,可溶于有机溶剂,但在水中溶解性有限;拉松聚钠具有抗微生物特性,特别是针对某些克模性细菌和蛋白,使其有效控制家禽和其他牲畜的共聚性;其行动机制涉及扰乱目标生物中的离子软骨,导致抑制或死亡;虽然一般认为该化合物在动物中安全使用,但在食品生产动物中应用以确保消费者安全方面有管制限制;此外,由于潜在的环境影响和微生物群中耐力的发展,该化合物的使用受到审查.
- 英文名称Lasalocid A Sodium Salt
- 中文名称拉沙洛西钠
- IUPAC名称Benzoic acid, 6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]tetrahydro-3-methyl-2-furanyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methyl-, monosodium salt
- 其它别名AVATEC; BOVATEC; LASAL°CID A SODIUM SALT; 5-dimethyl-6-oxononyl)--yl)tetrahydro-3-methyl-2-furyl)-4-hydroxy-monosodi; cresoticacid,6-(7-(5-ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2h-pyran-2; lasal°Cidsodium; lasal°Cidsodiumsalt
- CAS编号25999-20-6
- MFCD编号:MFCD00078065
- EINECS号:247-400-3
- FDA UNII编号:W2S5C71Y3G
- 分子式:C34H53NaO8分子量:612.77
- 产品CID: 1227472
- 同类组份化合物CAS73951-77-6 (acetate),62211-64-7 (anion)25999-31-9 (free acid)25999-20-6 (sodium)83198-76-9 (potassium)
- 产品分类原料药 → 抗寄生虫病药 → 抗原虫药
物理性质
- 熔点180 °C (分解)(文献)
- 沸点735.7 °C at 760mmHg
- 闪点224.8 °C
- 密度1.119g/cm3
- PSA:136.35
- LogP:4.5075
- 折射率1.528
- 蒸汽压1.01E-22mmHg at 25°C
- 溶解性DMSO:100.0(Max Conc. mg/mL);163.19(Max Conc. Mm)
- 外观形态类白色至浅米色固体
- 储存条件0-6°C
- 产品应用沙拉洛西钠作为抗球虫药,可用于16周龄以下的鸡饲料,用量为75(7500×104U)-125(12500×104U)g/t,产蛋期禁用,停药期5天.马属动物忌用,用后会致死.
- 性质描述白色至棕色粉末,有特异臭,熔点191-192°C(分解).微溶于水,可溶于大部分有机溶剂.性能稳定,37°C下可保存6个月不变,25°C下保存18月不变.小白鼠经口LD50146mg/kg,鸡经口LD5075-112mg/kg.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-119751196-A
优先权日:2025-01-08
标 题:A method for photocatalytic synthesis of 2-(bromomethyl)naphthalene
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Wang W, Song Y, Petrovski K, Eats P, Trott DJ, Wong HS, Page SW, Perry J, Garg S. Development of intramammary delivery systems containing lasalocid for the treatment of bovine mastitis: impact of solubility improvement on safety, efficacy, and milk distribution in dairy cattle. Drug Des Devel Ther. 2015 Jan 22;9:631-42. doi: 10.2147/DDDT.S74731. eCollection 2015.
2: Clark SB, Storey JM, Carr JR, Madson M. Analysis of lasalocid residues in grease and fat using liquid chromatography-mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(8):1243-8. doi: 10.1080/19440049.2015.1052572. Epub 2015 Jun 9. doi: 10.1016/j.chemosphere.2014.12.032. Epub 2014 Dec 30. doi: 10.4315/0362-028X.JFP-14-169. doi: 10.1016/j.saa.2014.01.083. Epub 2014 Jan 24. doi: 10.1021/ja511374k. Epub 2014 Dec 31. doi: 10.2527/jas.2015-9694. doi: 10.1136/vr.102508. Epub 2014 Aug 25. doi: 10.1016/j.chemosphere.2013.04.007. Epub 2013 Apr 29. doi: 10.1155/2013/783519. Epub 2012 Dec 30.
13: Rutkowski J, Huczyński A, Ratajczak-Sitarz M, Katrusiak A, Brzezinski B, Bartl F. Spectroscopic studies of the equilibrium between complexes of lasalocid acid with propargylamine and metal cations. Spectrochim Acta A Mol Biomol Spectrosc. 2015;150:704-11. doi: 10.1016/j.saa.2015.05.099. Epub 2015 Jun 9. doi: 10.1080/19440049.2011.653987. Epub 2012 Feb 27. doi: 10.1016/j.cbpa.2013.06.004. Epub 2013 Jun 21. Review. doi: 10.1016/j.bmcl.2013.07.040. Epub 2013 Jul 26. doi: 10.1021/ja301386g. Epub 2012 Apr 20. doi: 10.1111/j.1939-1676.2012.00933.x. Epub 2012 Apr 21. doi: 10.1080/19440049.2012.719641. Epub 2012 Sep 10. doi: 10.1016/j.saa.2012.11.106. Epub 2012 Dec 8.
合成参考文献
摘要:Kirk-Othmer Encyclopedia of Chemical Technology, 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978, 3(47), 1978
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