CAS: 21962-45-8; 4-Formyl-3-Methoxybenzonitrile

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CAS号914106-35-7 4-二溴甲基-3-甲氧基苯甲腈 | CAS号102361-94-4 Benzoyl chlorid... | CAS号3556-60-3 3-甲氧基-4-甲基苯腈 | CAS号626-02-8 3-碘苯酚 | CAS号38170-02-4 2-羟基-4-碘苯甲醛 | CAS号84102-89-6 3-羟基-4-甲酰基苯腈

4-(Hydroxymethyl)-3-Methoxybenzonitrile置于manganese(Iv) Oxide体系中,用 二氯甲烷 用作溶剂,化学反应 8.0H,以53 G的收率获得4-氰基-2-甲氧基苯甲醛
参考文献:一种2-甲氧基-4-氰基苯甲醛的合成方法
标题:一种2-甲氧基-4-氰基苯甲醛的合成方法
摘要:本发明公开了一种2‑甲氧基‑4‑氰基苯甲醛的合成方法,所述方法包含以下步骤:步骤1:以4‑甲基‑3‑甲氧基苯甲酸为原料,酰氯化反应,再氨解得到4‑甲基‑3‑甲氧基苯甲酰胺(ⅰ);步骤2:4‑甲基‑3‑甲氧基苯甲酰胺(ⅰ)进行脱水反应得到4‑甲基‑3‑甲氧基苯甲腈(ⅱ);步骤3:溴取代4‑甲基‑3‑甲氧基苯甲腈(ⅱ)的甲基上的氢得到4‑溴甲基‑3‑甲氧基苯甲腈(ⅲ);步骤4:4‑溴甲基‑3‑甲氧基苯甲腈(ⅲ)的溴甲基发生水解反应得到4‑羟甲基‑3‑甲氧基苯甲腈(ⅳ);步骤5:4‑羟甲基‑3‑甲氧基苯甲腈(ⅳ)发生氧化反应得到2‑甲氧基‑4‑氰基苯甲醛(ⅴ).本发明具有工艺路线设计合理,原辅料廉价易得,易操作,成本低,适于工业化生产等优点.

专利信息

专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人：WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:WO-2023109968-A3
优先权日:2021-12-18
标 题:Synthesis method for finerenone and intermediate thereof
发明人：RUAN SHIWEN; ZHANG WEI; YAN GONGCHAO; ZHANG XINXIN
权利人:SHANGHAI DINGYA PHARMACEUTICAL CHEMICALS CO LTD
摘要:The invention provides a new synthesis method for a finerenone intermediate. The method comprises: (1) in the presence of an acid and in an inert solvent or under solvent-free conditions, reacting diethyl malonate, 4-cyano-2-methoxybenzaldehyde and 4-amino-5-methyl-2-hydroxypyridine to prepare compound 1; (2) subjecting compound 1 obtained in step (1) and triethyl orthoformate to an alkylation reaction in an inert solvent or under solvent-free conditions under the catalysis of an acid to obtain compound 2; (3) reducing compound 2 obtained in step (2) by using a reducing agent to obtain compound 3; and (4) in the presence of a catalyst, subjecting compound 3 and alcohol to chemical resolution to prepare chiral compound 4. The reaction formula is shown as follows: . By means of the technical solution of the present invention, the use of a chiral column resolution method is avoided, so that the cost is reduced; and by means of the chemical resolution, the loss of raw materials is reduced, the post-treatment is simple, and industrial large-scale production is facilitated.

专利号:US-7951827-B2
优先权日:2005-05-05
标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
发明人：TIDWELL RICHARD R; BAKUNOVA SVETLANA M; BAKUNOV STANISLAV; PATRICK DONALD A
权利人:UNIV NORTH CAROLINA
摘要:Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

专利号:WO-2021045879-A1
优先权日:2019-09-03
标 题 :Synthesis of deuterated aldehydes

专利号:CN-119751447-A
优先权日:2024-12-23
标 题 :Method for asymmetric catalytic synthesis of naphthyridine carboxamide drugs

专利号:CN-119751447-B
优先权日:2024-12-23
标 题 :Method for asymmetric catalytic synthesis of naphthyridine carboxamide drugs