CAS: 19817-92-6; Uridine-5'-Triphosphoric Acid Trisodium Salt

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专利信息

专利号:US-2025243525-A1
优先权日:2022-06-24
标 题 :Biocatalytic manufacture of sugar nucleotides
发明人：HOEPKER ALEXANDER CHRIS; CILA MEGHA; GISKA FABIAN
权利人:ZYMTRONIX CATALYTIC SYSTEMS INC
摘要:The invention provides the production of sugar-nucleotides and the isolation of sugar-nucleotides. In some embodiments the production or isolation are accomplished under acidic conditions. The production is a cell-free synthesis using enzymes, including immobilized enzymes. They may be accomplished using a one-pot reaction protocol. The synthesis may be used as a highly customizable and highly efficient cell-free manufacturing process. In some embodiments, the sugar-nucleotides are used to prepare UDP-Gal, lactose derivatives, and human milk oligosaccharides (HMOs).

专利号:US-8193338-B2
优先权日:2006-07-26
标题:Process for producing di(pyrimidine nucleoside 5'-)polyphosphate
发明人：KOGO SATORU; YAMADA KOHEI; IWAI YUKO; OSAWA KAZUOMI; HAYAKAWA HIROYUKI
权利人:KOGO SATORU; YAMADA KOHEI; IWAI YUKO; OSAWA KAZUOMI; HAYAKAWA HIROYUKI; YAMASA CORP
摘要:A di(pyrimidine nucleoside 5′-)polyphosphate is synthesized by converting a pyrimidine nucleoside 5′-triphosphate into a pyrimidine nucleoside 5′-cyclic triphosphate by use of a condensing agent, and subsequently reacting the pyrimidine nucleoside 5′-cyclic triphosphate with a pyrimidine nucleotide in the presence of a salt of a metal selected from among magnesium, manganese, and iron. Through the method of the invention, a di(pyrimidine nucleoside 5′-)polyphosphate can be synthesized from an unprotected pyrimidine nucleoside 5′-phosphate serving as a starting material at a synthesis yield of 50% or higher. Therefore, the method of the invention is suitable for large-scale synthesis of a di(pyrimidine nucleoside 5′-)polyphosphate.