CAS: 19012-03-4; 1-Methyl-1H-Indole-3-Carbaldehyde

上下游产品

CAS号603-76-9 1-甲基吲哚 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号487-89-8 3-吲哚甲醛 | CAS号74-88-4 碘甲烷 | CAS号72010-39-0 N-methyl-N-[(1-... | CAS号19293-60-8 3-(氨基甲基)-1-甲基吲哚 | CAS号875-30-9 1,3-二甲基-1H-吲哚 | CAS号616-38-6 碳酸二甲酯 | CAS号77-78-1 硫酸二甲酯 | CAS号38292-40-9 1,2-二甲基-1H-吲哚-3-甲醛 | CAS号51584-17-9 1-甲基吲哚-3-乙腈 | CAS号2731-00-2 1H-Indole,1-met... | CAS号875-30-9 1,3-二甲基-1H-吲哚 | CAS号7518-21-0 2-(1-甲基-1H-吲哚-3-基)乙胺 | CAS号128965-49-1 1-methyl-3-(2-n... | CAS号103907-05-7 [(1-methylindol... | CAS号19293-60-8 3-(氨基甲基)-1-甲基吲哚 | CAS号26988-72-7 1-甲基-色氨酸 | CAS号24662-37-1 1-甲基-1H-吲哚-3-甲腈

(1-甲基-1H-吲哚-3-基)甲胺置于三乙烯二胺,二甲基硫,氧气体系中,用 二甲基亚砜 用作溶剂,100.0 °C,101.33 Kpa 条件下,反应 24.0H,以98%的收率获得1-甲基吲哚-3-甲醛
参考文献:铜催化的好氧甲基/亚甲基氧化和dabco-Dmso体系的ch甲酰化反应,用于羰基吲哚和吡咯的合成
标题:铜催化的好氧甲基/亚甲基氧化和dabco-Dmso体系的ch甲酰化反应,用于羰基吲哚和吡咯的合成
摘要:摘要 使用1,4-二氮杂双环[2.2.2]辛烷(dabco)作为二甲基亚砜(dmso)的添加剂,开发了铜催化的取代吲哚和吡咯的甲基/亚甲基氧合反应.类似的有氧催化条件也可以用于吲哚的c(3)和吡咯的c(2)的直接c-h甲酰化. 使用1,4-二氮杂双环[2.2.2]辛烷(dabco)作为二甲基亚砜(dmso)的添加剂,开发了铜催化的取代吲哚和吡咯的甲基/亚甲基氧合反应.类似的有氧催化条件也可以用于吲哚的c(3)和吡咯的c(2)的直接c-h甲酰化.
Doi:10.1055/s-0031-1290815

专利信息

专利号:US-7714063-B2
优先权日:2007-11-15
标 题 :Solid support for Fmoc-solid phase synthesis of peptides
发明人：SRIVASTAVA KRIPA SHANKER; DAVIS MATTHEW RYAN
权利人:MALLINCKRODT INC
摘要:The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides.

专利号:US-6121054-A
优先权日:1997-11-19
标 题 :Method for separation of liquid and solid phases for solid phase organic syntheses
发明人：LEBL MICHAL
权利人:TREGA BIOSCIENCES INC
摘要:A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-11117893-B2
优先权日:2018-09-24
标题 :Methods for preparation of substituted pyridines and related novel compounds
发明人：WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY
权利人:WATKINS EDMOND BLAKE; UREDI DILIPKUMAR; MOTATI DAMODER REDDY; UNION UNIV
摘要:The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

专利号:US-6045755-A
优先权日:1997-03-10
标题 :Apparatus and method for combinatorial chemistry synthesis
发明人：LEBL MICHAEL; POKORNY VIT; KRCHNAK VIKTOR
权利人:TREGA BIOSCIENCES INC
摘要:In a first embodiment, this invention includes an integrated robot apparatus for performing combinatorial chemistry synthesis protocols and having interchangeable work-stations, robot arm tools, and reaction vessels and reaction vessel arrays. The work-stations and tools are specialized to perform tasks necessary for the synthesis in a plurality of the reaction vessels grouped in a plurality of the reaction vessel arrays. Preferably, these elements function interchangeably because they have standardized sizes and conformation. The work-stations and tools include those for fluid dispensing or aspirating from individual reaction vessels or from all the reaction vessels in an array simultaneously. The reaction vessels can include, alternatively, stackable, ball-sealed reaction vessels, microtitre-like reaction vessel arrays, arrays of independent reaction vessels, valve-sealed reaction vessels, septum-sealed reaction vessels, and syringe reaction vessels. In alternative embodiments, this invention includes these work-stations, tools, reaction vessels and reaction vessel arrays in various combinations or sub-combinations either for use in partially integrated robots or for manual or standalone use.

专利号:US-2022396818-A1
优先权日:2019-09-10
标 题:Polynucleotide synthesis method, kit and system
发明人：MILTON JOHN; NAYYAR SOBIA; RIEDL JAN; OGAKI RYOSUKE; WILKINSON MARC GEORGE
权利人:OXFORD NANOPORE TECH PLC
摘要:The invention relates to new methods for synthesising polynucleotide molecules according to a predefined nucleotide sequence. The invention also relates to methods for the assembly of synthetic polynucleotides following synthesis, as well as systems and kits for performing the synthesis and/or assembly methods.