CAS: 1877-71-0; 3-(Methoxycarbonyl)Benzoic Acid

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CAS号1459-93-4 间苯二甲酸二甲酯 | CAS号201230-82-2 carbon monoxide | CAS号618-89-3 3-溴苯甲酸甲酯 | CAS号585524-77-2 3-甲氧羰基苯硼酸新戊二醇酯 | CAS号124-38-9 二氧化碳 | CAS号5453-67-8 2,6-吡啶二甲酸二甲酯 | CAS号6018-41-3 香豆灵酸甲酯 | CAS号79-10-7 丙烯酸 | CAS号13531-48-1 3-氰基苯甲酸甲酯 | CAS号131-11-3 邻苯二甲酸二甲酯； 避蚊酯 | CAS号41221-47-0 3-羧甲氧基苯基异氰酸酯 | CAS号3441-03-0 3-(氯羰基)苯甲酸甲酯 | CAS号28286-79-5 3-羟甲基苯甲酸 | CAS号67853-03-6 3-羟甲基苯甲酸甲酯 | CAS号126926-35-0 3-[(Dipropylami... | CAS号126926-42-9 Methyl 3-(dipro... | CAS号159782-00-0 3-(4-氟苯甲酰基)苯甲酸 | CAS号106748-24-7 3-氨基甲酰基苯甲酸甲酯 | CAS号1459-93-4 间苯二甲酸二甲酯 | CAS号1129-28-8 3-溴甲基苯甲酸甲酯

3-甲基磺酰基-苯甲酸甲酯置于新铜试剂,[nibr2(2,9-Dimethyl-1,10-Phenanthroline)],锌体系中,用 二氯甲烷,二甲基亚砜 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 16.0H,反应生成间苯二甲酸单甲酯
参考文献:Ni催化c(sp 2)-s键与co 2的羧基化:Zn的多方面作用的证据
标题:Ni催化c(sp 2)-s键与co 2的羧基化:Zn的多方面作用的证据
摘要:芳基亲电子试剂的镍催化的还原羧化反应通常需要使用金属还原剂.目前,普遍的看法是它们既可以作为电子来源,又可以作为路易斯酸的来源,可以帮助co 2插入ni-C键.本文中,我们提供了从金属还原剂原位形成有机金属物种的证据,该步骤在与金属粉末还原剂的催化羧化反应中已经被排除或未被探索.具体来说,我们证明zn(0)充当还原剂,并且zn(II)生成可能在芳基ulf盐的c(sp 2)-S羧化反应中起作用的芳基锌物质.总体而言,还原性镍催化的c(sp 2)-s羧化反应在温和的条件下在非酰胺溶剂中进行,显示出较宽的底物范围,可用于芳烃的正式对位c-h羧化反应.
Doi:10.1021/acscatal.9B05141

专利信息

专利号:US-9000209-B2
优先权日:2011-07-22
标题:Method of regioselective synthesis of substituted benzoates
发明人：KRAUS GEORGE A
权利人:KRAUS GEORGE A; UNIV IOWA STATE RES FOUND INC
摘要:A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.

专利号:US-8114993-B2
优先权日:2007-02-06
标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization
发明人：DAUGULIS OLAFS; CHIONG HENDRICH
权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM
摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.

专利号:WO-2021123883-A1
优先权日:2019-12-19
标 题 :Macrocyclic amides acting as plasmepsin inhbitors for the treatment of malaria
发明人：JIRGENSONS AIGARS; KOVADA VADIMS; BOBROVS RAITIS; SUNA EDGARS; JAUDZEMS KRISTAPS; RASINA DACE; ZOGOTA RIMANTS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to medicine and in particular to the treatment of malarial infections, more particularly to inhibitors of malarial aspartic proteases - plasmepsins. Even more particularly, the invention relates to macrocyclic amides and pharmaceutical compositions thereof and their use as inhibitors for plasmepsins (Plm).

专利号:US-2007265419-A1
优先权日:2006-05-10
标 题:Process for driving gas blowers or fans in a solid-state polymerization process using steam from a terephthalic acid plant
发明人：BONNER RICHARD G; DEBENPORT ALBERT B
权利人:BONNER RICHARD G; DEBENPORT ALBERT B
摘要:A method for integrating energy resources between a process for synthesizing terephthalic acid and a process for the solid-state polymerization of a polyester, which comprises generating steam from the synthesis of terephthalic acid, providing the steam to a condensing turbine to generate power, applying the power to a gas blower or fan to create a stream of gas and applying the stream of gas to fluidize polyester pellets in a crystallization and/or solid-state polymerization process.

专利号:US-8653223-B2
优先权日:2008-04-16
标题:Transketalized compositions, synthesis, and applications
发明人：SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG
权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC
摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.

专利号:US-8952042-B2
优先权日:2009-08-19
标 题 :FXR (NR1H4) binding and activity modulating compounds
发明人：KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF
权利人:KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF; PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds of formula (1): n nwhere R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.