CAS: 17817-31-1; 6,7-Dihydroxy-3-(4-Hydroxyphenyl)-4H-Chromen-4-One

上下游产品

CAS号486-66-8 大豆苷元 | CAS号40957-83-3 黄豆黄素 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号290-87-9 1,3,5-三嗪 | CAS号67-56-1 甲醇 | CAS号550-79-8 7-羟基-6,4'-二甲氧基异黄酮 | CAS号40957-83-3 黄豆黄素 | CAS号970-48-9 4',7-DIMETHOXY-... | CAS号798-61-8 4',6,7-三甲氧基异黄酮

📜对羟基苯乙腈置于盐酸,三氟化硼乙醚,水,甲基磺酰氯,Zinc(II) Chloride体系中,用 乙醚 用作溶剂,化学反应 2.0H,反应生成4',6,7-三羟异黄酮
参考文献:Enzymatic Studies Of Isoflavonoids As Selective And Potent Inhibitors Of Human Leukocyte 5-Lipo-Oxygenase
标题:Enzymatic Studies Of Isoflavonoids As Selective And Potent Inhibitors Of Human Leukocyte 5-Lipo-Oxygenase
摘要:Continuing Our Search To Find More Potent And Selective 5‐lox Inhibitors,We Present Now The Enzymatic Evaluation Of Seventeen Isoflavones (Ir) And Nine Isoflavans (Hir),And Their In Vitro And In Cellulo Potency Against Human Leukocyte 5‐lox. Of The 26 Compounds Tested,10 Isoflavones And 9 Isoflavans Possessed Micromolar Potency,But Only Three Were Selective Against 5‐lox (Ir‐2,Hir‐303,And Hir‐309),With Ic50 Values At Least 10 Times Lower Than Those Of 12‐lox,15‐lox‐1,And 15‐lox‐2. Of These Three,Ir‐2 (6,7‐dihydroxy‐4‐methoxy‐isoflavone,Known As Texasin) Was The Most Selective 5‐lox Inhibitor,With Over 80‐fold Potency Difference Compared With Other Isozymes; Steered Molecular Dynamics (Smd) Studies Supported These Findings. The Presence Of The Catechol Group On Ring A (6,7‐dihydroxy Versus 7,8‐dihydroxy) Correlated With Their Biological Activity,But The Reduction Of Ring C,Converting The Isoflavones To Isoflavans,And The Substituent Positions On Ring B Did Not Affect Their Potency Against 5‐lox. Two Of The Most Potent/selective Inhibitors (Hir‐303 And Hir‐309) Were Reductive Inhibitors And Were Potent Against 5‐lox In Human Whole Blood,Indicating That Isoflavans Can Be Potent And Selective Inhibitors Against Human Leukocyte 5‐lox In Vitro And In Cellulo.
Doi:10.1111/cbdd.12469

专利信息

专利号:US-9102961-B2
优先权日:2009-03-11
标 题 :Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
发明人：BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN M
权利人:CELEXION LLC
摘要:Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.

专利号:US-2013017593-A1
优先权日:2009-03-11
标题:Biological Synthesis of Difunctional Hexanes and Pentanes from Carbohydrate Feedstocks

专利号:US-2014212934-A1
优先权日:2009-03-11
标 题 :Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks

专利号:US-2015252392-A1
优先权日:2009-03-11
标 题:Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks

专利号:US-2012301950-A1
优先权日:2009-03-11
标 题:Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks

专利号:US-8404465-B2
优先权日:2009-03-11
标 题 :Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks