CAS: 1733-57-9; Ethyldiphenylphosphine Oxide

上下游产品

Ethyl diphenylphosphinite diphenyl-phosphinic acid ethyltriphenylphosphonium iodide ethyl iodide1,1-diphenyl-1-propene ethyl(phenyl)phosphinic acid 1-[1-(Diphenyl-phosphinoyl)-ethyl]-cyclohexanol (1RS,2SR)-1-phenyl-2-(diphenylphosphinoyl)propan-1-ol

📜二苯基乙氧基膦置于三氟甲磺酸体系中,化学反应 16.0H,以80%的收率获得乙基二苯基氧化膦
参考文献:水决定了产物:意外的布朗斯台德酸催化p(III)酯的po-R裂解,选择性地产生p(o)-H和p(o)-R化合物
标题:水决定了产物:意外的布朗斯台德酸催化p(III)酯的po-R裂解,选择性地产生p(o)-H和p(o)-R化合物
摘要:发现水能够确定布朗斯台德酸催化的亚磷酸三烷基酯的c-O裂解反应的选择性:与水一起,该反应在室温下迅速发生,从而定量获得h-膦酸酯的收率.在不加水的情况下,该反应选择性地以高收率提供了烷基膦酸酯,为著名的michaelis-Arbuzov反应提供了一种新型的无卤化物替代方案.该方法是通用的,因为它可以很容易地扩展到亚膦酸酯和次膦酸酯以及大规模的反应,而催化剂的负载却低得多,从而能够简单,有效和实用地制备相应的有机磷化合物.
Doi:10.1039/c9Gc01254K

专利信息

专利号:US-5446158-A
优先权日:1989-01-11
标题:Process for synthesis of FK-506 and tricarbonyl intermediates
发明人：JONES TODD K; MILLS SANDER G; ASKIN DAVID; REAMER ROBERT A; DESMOND RICHARD; TSCHAEN DAVID M; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.

专利号:US-4594432-A
优先权日:1983-01-28
标题 :Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
发明人：BAGGIOLINI ENRICO G; USKOKOVIC MILAN R; WOVKULICH PETER M
权利人:HOFFMANN LA ROCHE
摘要:The invention is directed to a process and intermediates for the preparation of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol. The end-products, 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol, are useful for the treatment of disease states which are characterized by insufficient amounts of 1,25 dihydroxycholecalciferol.

专利号:US-4595776-A
优先权日:1983-03-21
标 题:Synthesis of 1α,25-dihydroxyergocalciferol
发明人：BAGGIOLINI ENRICO G; BATCHO ANDREW D; BORIS ALFRED; USKOKOVIC MILAN R
权利人:HOFFMANN LA ROCHE
摘要:The invention is directed to a process and intermediates for the preparation of 1 alpha ,25-dihydroxyergocalciferol as well as substantially pure and crystalline 1 alpha ,25-dihydroxyergocolciferol. The end-product 1 alpha ,25-dihydroxyergocalciferol is useful in the treatment of disease states which are characterized by insufficient amounts of 1 alpha , 25-dihydroxycholecalciferol.

专利号:US-11827660-B2
优先权日:2019-02-01
标题 :Synthesis strategy for gap protecting group
发明人：SEIFERT COLE
权利人:SEDERMA SA
摘要:The present invention relates to a novel synthesis method to form particular molecules. These molecules have multiple uses, most notably in the field of protecting groups used throughout organic and synthetic chemistry. The disclosed method is safer, more cost- and time-effective, and more amenable to large scale production than those currently known in the art. The protecting groups synthesized are useful in GAP peptide synthesis.

专利号:WO-2010074764-A1
优先权日:2008-12-23
标题 :Synthesis of oligomeric neolignans and their use
发明人：SNYDER SCOTT A; KONTES FERENC
权利人:UNIV COLUMBIA; SNYDER SCOTT A; KONTES FERENC
摘要:Compounds having the structure formule (I) and their uses are described herein.

专利号:KR-0160937-B1
优先权日:1991-05-28
标 题:New Synthesis of 19-Nor Vitamin D Compounds