专利号:US-12351573-B2 优先权日:2019-05-09 标 题:Compounds for use in synthesis of peptidomimetics 发明人:AL-ABED YOUSEF; CHENG KAI FAN 权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH 摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.
专利号:US-11440881-B2 优先权日:2019-05-09 标题 :Thiosemicarbazates and uses thereof 发明人:AL-ABED YOUSEF; ALTITI AHMAD 权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH 摘要:Thioesters, thiocarbamates, thiocarbazates, semithiocarbazates, peptides, aza-amino acid conjugates, and azapeptides; and a chemoselective and site-specific functionalization protocol of protected thiocarbazates and semithiocarbazates are described. The protocol features the use of Mitsunobu reaction to alkylate specifically the nitrogen atom close to the acylthiol moiety with alcohols to produce protected mono-substituted thiocarbazates that can be stored for months, activated under mild conditions at low temperature using halonium reagents and integrated orthogonally to make substituted semicarbazides that can be used, e.g., as synthons in synthesis of aza-amino acid conjugates, azapeptides and other peptidomimetics. Methods for preparing and using ureases, carbazides, semicarbazides, beta-peptides, azapeptides, and other peptidomimetics and azapeptide conjugates, and uses of ureases, carbazides, semicarbazides, beta-peptides, azapeptides in drug discovery, diagnosis, inhibition, prevention and treatment of diseases are also described.
专利号:US-2022372022-A1 优先权日:2019-05-09 标 题:Compounds for use in synthesis of peptidomimetics
专利号:US-10919882-B2 优先权日:2019-05-09 标题:Compounds for use in synthesis of peptidomimetics
专利号:WO-2020227594-A1 优先权日:2019-05-09 标 题:Compounds for use in synthesis of peptidomimetics
专利号:DE-102016209814-A1 优先权日:2016-06-03 标 题:Two-step synthesis of N-biaryl compounds
[参考文献]: Yasuyuki Miura, Et Al. Rapid Ion Chromatography Of L-Ascorbic Acid, Nitrite, Sulfite, Oxalate, Iodide And Thiosulfate By Isocratic Elution Utilizing A Postcolumn Reaction With Cerium(Iv) And Fluorescence Detection. J Chromatogr A. 2002 May 17;956(1-2):77-84.