专利号:US-11548898-B2 优先权日:2017-07-06 标题 :Synthesis of halichondrins 发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI 权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD 摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).
专利号:US-4749806-A 优先权日:1984-12-28 标题:Process for the synthesis of isocyanates and of isocyanate derivatives 发明人:TKATCHENKO IGOR; JAOUHARI RABIH; BONNET MICHEL; DAWKINS GORDON; LECOLIER SERGE 权利人:POUDRES & EXPLOSIFS STE NALE 摘要:The present invention relates to a process for the synthesis of isocyanates and of isocyanate derivatives. Isocyanates are obtained by reacting an organic halide with a metal cyanate in an organic medium in the presence of a catalyst consisting of a complex of nickel with at least one organic ligand, in which complex the nickel is in the zero oxidation state. A carbamate or a urea, respectively, are obtained by a subsequent reaction with a hydroxy compound or a primary or secondary amine. Isocyanates and their derivatives are used especially either as refined synthesis agents for the production of pesticides and medications, or as monomers or comonomers for the preparation of many macromolecular compounds.
专利号:US-7022871-B2 优先权日:1999-12-27 标 题 :Process for the synthesis of polycarbamates 发明人:CHAUDHARI RAGHUNATH VITTHAL; KELKAR ASHUTOSH ANANT; GUPTE SUNIL PURUSHOTTAM; DIVEKAR SUNIL SADASHIV; GANAPATHY SUBRAMANIAN 权利人:HUNTSMAN INT LLC 摘要:Process for the synthesis of polyurethane derivatives from aromatic polyamine compounds. The method involves the reaction of an aromatic polyamine compound with CO and O 2 in the presence of a catalyst comprising a Group VIII or lanthanide metal on a solid support and a halogenide promoter.
专利号:EP-1242368-B1 优先权日:1999-12-27 标 题 :Process for the synthesis of polycarbamates 发明人:CHAUDHARI RAGHUNATH VITTHAL; KELKAR ASHUTOSH ANANT; GUPTE SUNIL PURUSHOTTAM; DIVEKAR SUNIL SADASHIV; GANAPATHY SUBRAMANIAN 权利人:HUNTSMAN INT LLC 摘要:Process for the synthesis of polyurethane derivatives from aromatic polyamine compounds. The method involves reaction of an aromatic polyamine compound with CO and O2 in the presence of a catalyst comprising a Group VIII or lanthanide metal on a solid support and a halogenide promoter.
专利号:US-5171676-A 优先权日:1991-10-31 标 题 :Method of introducing hydroxyl groups into artemisinin and its derivatives 发明人:ZIFFER HERMAN; HU YULIN 权利人:US HEALTH 摘要:The fungus Beauveria sulfurescens has been employed to introduce hydroxyl groups into artemisinin and derivatives of artemisinin, an antimalarial. Hydroxylated derivatives of artemisinin and derivatives of artemisinin produced thereby possess antimalarial activity, and can serve as intermediates in the synthesis of further derivatives useful in treating malaria.
专利号:US-8106031-B2 优先权日:2006-05-02 标题:Hydrolytically-resistant boron-containing therapeutics and methods of use 发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A 权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC 摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要:Thullen, S. M.; Ashley, M. A.; Rovis, T., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 240. 摘要:Clark, K. F.; Dimitrova, D.; Murphy, J. A., Science of Synthesis, (2020) , 2. 摘要:Galczynski, J.; Huang, H.; Lambert, T. H., Science of Synthesis: Special Topics, (2021) 1, 330. 摘要:Oakwood Products, Inc; Fine Organics Manufacturing Facility. Available at 摘要:Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 14th Edition. John Wiley & Sons, Inc. New York, NY 2001., p. 476